Create a reproducible characterization test for your biosensor
Test different reagents with our Distribution Valve
Get more assays and less contamination for your experiments
Analyze multiple samples or detect multiple reagents
Image Credit: J. Adam Fenster / University of Rochester. Licence: Attribution 4.0 International (CC BY 4.0)
Image Credit: Norovirus – colour-enhanced. David Gregory & Debbie Marshall. Licence: Attribution 4.0 International (CC BY 4.0)
This beta pack is dedicated to the test, characterization, and calibration of biosensors with small volumes, reproducibility, and automatization. We have sought to create a system that unifies and automates the tests necessary to calibrate any biosensor based on Elveflow instruments.
The main objective of this pack is to create a scalable system that allows you to accurately calibrate a biosensor through microfluidic technology. With this system, you can test different solutions (drugs or reagents at different concentrations) in order to calibrate or test your biosensor in an easy way. In addition, this system can be adapted to test any fluid, liquid or gaseous in order to calibrate a biosensor for any application with a sequential fluid Injection system.
AN ALL-IN-ONE PACK TO EASILY TEST YOUR BIOSENSOR
Biosensors are analytical devices that have taken on an important role in the biotechnology sector. This is because they have a wide variety of applications and can be adjusted to different criteria of sensitivity and precision. Biosensors are responsible for converting biochemical signals into signals that can be quantified, which are typically electrical or optical signals. It is for this reason that biosensors must be properly calibrated in order to quantify and minimize the error in each one of them. For this reason, it is necessary to develop an automated system that allows performing different tests to optimize the performance of a biosensor. This is an important activity since one of the most important activities of a biosensor is to obtain accurate information in real-time about the measurements it performs. Also, because a biosensor uses different biological components, it is necessary to take into account a cleaning system between each calibration test.
While for a proof of concept, manual testing works very well, this requires a lot of pipetting time that you may want to get rid of for scalability reasons. As soon as you need more accurate professional biosensor testing, an automated system can take you to the next level ensuring better control and accuracy in calibration.
In general, microfluidics will allow you to have high precision because thanks to a microfluidic pump you can control the flow of each sample precisely. This will decrease the variability between results and increase the accuracy obtained in each of the measurements. Similarly, through a microfluidic system, you can decrease the test time by increasing the transport speed of the samples.
In addition, this microfluidic system will allow you to obtain great flexibility since it can be adapted to each biosensor you want to calibrate and at the same time to the specifications of each application. Thanks to the performance of this set of equipment, you will be able to control all the parameters that you need.
If you already want to start testing your biosensors you can explore the different configurations that this Elveflow beta pack has for you.
If you already want to start with the setup of this beta pack you can check the following examples of sensor calibration beta packs on different types of microfluidic chips and type of experiments. In general, these are based on the calibration through the injection of different types of samples thanks to the sequential injection system. For more detailed information, please contact our experts or check our multiple fluid switching application pack.
Depending on the intended application of your biosensor it is important that you choose how you want your biosensor testing system to perform. For example, this setup can be used when you want to test a biosensor by varying the input substances.
With our beta pack you will be able to test different liquids in your biosensor. However, if you then wish to vary the concentration, you can consult our beta pack for concentration calibration in biosensors.
Each Pack is composed of:
Hardware:
Contact our experts to answer any questions about this biosensor testing pack and how it can match your specifications!
To perform any experiment involving a biosensor it is important to first test its performance. This activity will allow you to determine how sensitive and reliable your sensor will be to different samples. To determine the functionality of your biosensor it is necessary to determine some parameters such as:
Once you have decided which parameters are most important for your research you can move on to using your microfluidic device along with a customized Elvwflow pack. All these parameters can be tested easily and automatically through our all-in-one kit. Normally, the main applications of this beta pack are based on the characterization of different samples that can be further enhanced thanks to the MUX distribution.
For example, you can place up to four biosensors (one biosensor for each channel) thanks to our OB1 pressure controller. It is important to mention that thanks to the high customization provided by this beta pack, these biosensors can be different or the same so that you can ensure the repeatability of your testing. Then, you can join up to 12 samples of different sizes and administer them sequentially to your biosensors.
This way, you can have automated testing of your biosensors in simple steps, compared to using a conventional system that will only allow you to test one sample on a biosensor per step. Therefore, with the biosensor testing pack you will optimize the testing time as well as the amount of samples you need. Microfluidic testing only requires tiny volumes of samples or reagents, so you can easily run different tests and automate them with each other.
It is important to note that because biosensors treat biological samples, it is necessary to have a buffer cleaning step between each test. This process generates more accurate and closer to reality results; however, it increases the testing process if a conventional calibration method is used.
For that reason, with the Elveflow beta pack you can save processing time as the buffer cleaning process can be easily included in the pack.
One of the most common applications for biosensors is based on the variation of the type of drug that these sensors can measure. Thanks to the beta test pack you can vary the type of drug to be tested to evaluate which one has a better performance for your experiment. Also, at the same time you can decide whether to test the performance of different biosensors as you can add up to 4 biosensors for simultaneous testing. The variation of drugs in experimentation has a high relevance and needs an accurate testing system like the one offered by this beta pack since this type of system can be used for the detection of drugs in biological fluids such as sweat, saliva, blood or urine. In addition, it can be used to ensure safety in the quality control process in drug production or in the food industry.
If you wish to go further with the testing of your biosensor you can consult our MUX cross chip and contact our experts who will help you determine which beta pack fits your needs.
Yes, parallelization can be achieved with this beta pack and will allow you to simultaneously analyze multiple samples or detect multiple analytes. By incorporating multiple samples a biosensor can increase its performance and efficiency, making it suitable for multiplexed analysis or simultaneous monitoring. This will allow you to have faster analysis of multiple samples, reduce the time required for data collection, and improve the overall sensitivity and specificity of the biosensor.
With our system it will be easier for you to obtain data so that you can obtain a calibration curve for your biosensor. Depending on the intended use of your biosensor, you can apply different types of configurations. For instance, if you want to test multiple sensors at the same time, you can add a manifold to distribute the inlet fluid to all the biosensors. Additionally, it is possible to add a valve to maximize the use of each pressure channel.
Moreover, it is possible to integrate a mixing chip before biosensor testing to perform concentration tests with different substances, as the chip will allow the fluids you choose to combine properly.
Furthermore, it is possible to add an external buffer substance input to have better control over the cleaning of each part of the system between each test.
Yes, this beta pack can be used together with any other Elveflow equipment since they are all compatible with each other. This feature allows you to adapt this pack to your needs.
Sterilization in biosensor testing is important to ensure the accuracy, reliability and safety of the tests you perform. In that sense, having good contaminant management can help you ensure reproducibility and comparability of results. For that reason, this beta pack considers the buffer cleaning steps in each test cycle of your biosensors. However, for specific applications just contact our expert to check if your method is suitable with our instruments or follow the protocol they will share with you.
Elveflow equipment is ready for you to use in a wide range of volumes, ranging from microliters to liters. However, to find out which Elveflow equipment and features match your applications, contact our experts.
Elveflow’s products and Beta packs are fully customizable so they will be perfectly adapted to your needs. Our specialists and researchers can help you choose the best instruments and accessories. In addition, they will accompany you during the setup of the microfluidic platform until you can get the experimental results you need.
Elveflow can provide you with a wide range of different flow sensors, bubble detectors and traps or any relevant microfluidic instrument for the applications you need.
Please contact our experts for any questions about this pack and how it can fit your specifications.
For any help to determine what microfluidic instruments you need, you can contact us! Our experts will help you build the best microfluidic setup for your application, with our state-of-the-art microfluidic line.
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