The Elveflow Smart Interface allows an intuitive control of our microfluidic instruments in few clicks.
Elveflow® is continuously shaping the developments of its products. We are actively looking for user insights to provide them with the products best suited to their needs.
Find here all you need to do, by yourself, your microfluidic devices.
ORGAN ON CHIP PACK : Elveflow® provides a pack dedicated to organ-on-chip. This fully integrated solution includes all the necessary elements to dive into this promising area.
Elveflow® provides a perfusion system dedicated to cell culture, for lab-on-chips and perfusion chambers.
The droplet pack has been designed to fit most common droplet generation needs of researchers.
The Starter Pack holds all necessary elements for you to start your own microfluidic experiments.
Fluorescence detection for microfluidic device : The FluoReader is a LED Induced Fluorescence (LEDIF) measuring system designed for microfluidic applications. Faster, more sensitive and less expensive than most optical microscopes, it is a smart alternative for real time optical measurement of medium-scale objects (mm scale).
Optical Reader for Microfluidics: the OptoReader brings about the strength of duplex optical fiber measurement, high optical sensitivity and real-time processing capacity within a compact design.
Elveflow provides a unique microfluidic bubble detector. It can identify if liquid is present in clear tubes. It can be plugged directly onto our OB1 flow controller, or it can be used as a standalone unit with the Sensor Reader and another instrument.
Get high accuracy flow through sensors for high accuracy pressure measurement and internal volume as small as 7.5 µL
Get inline liquid sensors for pressure measurement with no dead volume and FDA certified .
Elveflow® provides its customers with high accuracy liquid mass flow sensors for ultra low flow rate monitoring. Furnished with an M8 electrical connection, it can be controlled directly through the Elveflow® software to monitor the flow rate on your microfluidic experiment.
In partnership with Bronkhorst, we have developed a unique Coriolis flow sensor suited to microfluidics. It offers various benefits without concessions: precision, wide range, straightforward compatibility with all liquids (no calibration needed)...
The Sensor Reader is an interface allowing the acquisition of many kinds of analog sensors, including Elveflow pressure sensors and flow sensors.
Quake valve control, Medium switch, Live cell perfusion, Stop flow ... And any other experiment you can imagine !
At Elveflow, we specialize in high performance fluidic solutions. Our instruments and custom fluidic solutions are used worldwide by hundreds of academic laboratories and industrial partners.
The Dual AF1 has a pressure range from -700 mbar to 1bar. It can be used both as a vacuum source or a pressure source and enables you to switch from vacuum to pressure on the same channel.
An autonomous pump designed to meet any mobile worker's needs
Plug your valves wherever you want in your microfluidic setup
Elveflow® provides the only microfluidic flow control system in the world to use patented piezoelectric regulators, enabling a flow control that is 20 times more precise and 10 times faster than the other flow controllers on the market. You will never be limited by flow control factors in your experiments.
A wide range of experiments take advantage of drugs such as ricin or antibiotics to inhibit protein synthesis and monitor the effect of this inhibition on the cell's phenotype.
One major question in biology is how cells cope with rapid changes of their microenvironment.
Protein conformation is highly sensitive to pH. Thus modifying the pH of the medium perfusing the cells can alter their functions
Studies indicate that endothelial cells are sensitive to fluid shear stress, which triggers changes in cells shape
The ibidi Pump System is specialized in cell cultivation for simulation of blood vessels, and is ideal to simulate various physiological conditions for long term cell culture.
Fluorescent proteins are a powerful tool to investigate gene expression and protein localization in live cells.
Life Imaging Services provides products and services for live microscopy. The Ludin chamber is designed for high-resolution live microscopy.
ibidi is a leading supplier for functional cell-based assays and advanced products for cellular microscopy. They provide a large range of μ-Slides and μ-Dishes for live cell imaging.
Siskiyou provides perfusion chambers with a specific feature, which is embedded magnets that are located to retain perfusion plumbing and electrical grounds.
Everything you need to know about our all-in-one Perfusion Pack for live-cell imaging chambers or microfluidic chips
The easy manipulation of fission yeast, the short dividing time and the existence of a temperature-sensitive mutant strain allows the researcher to dissect the role of microtubules in various aspects of S. pombe biology.
The use of fission yeast temperature-sensitive mutants has contributed to the discovery of new genes involved in yeast biology. They also have been used to gain better understanding in essential gene function.
Temperature-sensitive mutant fission yeast is a commonly used genetics tool to study essential genes. It is a fast and effective technique to conditionally inactivate genes and question the role of any protein in a timely manner.
Cytokinesis is a cellular process during which the cytoplasm and chromosomes of a single cell are divided to generate two daughter cells. This mechanism is well conserved through evolution and requires the interaction between myosin motor II proteins and actin filaments to form a contractile ring.
ElveflowTemp allows you to quickly shift your fission yeast temperature from 5 to 45°C, it is published, easy to use and fits your existing microscope setting.
AN EXEMPLE USING FAST TEMPERATURE CONTROLLER FOR S. POMBE DYNAMIC CELL CYCLE CONTROL
With its precise and ultra-fast temperature switch, Elveflow offers you the possibility to activate thermo-sensitive ion channels while visualizing the downstream cellular effects with microscopy.
Viral infection begins with the attachment of viral particles to the host cell membrane.
Vesicular trafficking is a process spanning from the cellular membrane to the cell organelles. At the membrane level, endocytosis and exocytosis ensure cell communication with their environment, they also ensure receptors, ions channels, surface proteins and lipids membrane renewal. In the cytoplasm, vesicles travel along microtubules using motor proteins to shuttle to recycle organelles.
We developed a temperature control heater/cooler device that answers any type of cells needs for microscope imaging.
ElveflowTemp, our temperature controller, allows you to combine high-resolution microscope imaging with ultra-fast and precise temperature switch
With its unique transparency features and detailed biology, C. elegans is a choice model for biologists to study a whole animal using live cell imaging.
C. elegans is a powerful model to study genetic control of neuron lineage, or degenerative diseases.
With its perfectly documented cell-lineage development, C. elegans is a model of choice to study asymmetric cell division.
C. elegans mitosis control with thermosensitive mutants : Example of use of ultra fast temperature control
WHAT IF YOU COULD CHANGE THE TEMPERATURE OF YOUR FAVORITE WORM AND WATCH IT AS IT HAPPENS?
3D cell culture is a powerful tool to more closely mimic the in vivo environment of the cells.
The detection of microparticles in a flow is a routine task in many domains, e.g. cell biology, chromatography, medical and environmental research, etc. This task is commonly performed on conventional epi-fluorescence microscopy which is highly precise but is space consuming, requires an important investment and is confusing for non-experts.
The Opto Reader allows the detection and quantification of flowing particles at a given point during microfluidic experiments. The optical fiber both illuminates and captures light emitted by a fluorescent object. The optical fiber output can be focalized into a tiny spot thanks to a compact objective specifically designed for microfluidic chips.
Droplets generation has a large range of applications, such as emulsion production, single cell analysis, drug delivery or nanoparticles synthesis. Droplets can also be used as micro bioreactors for chemical or biochemical reactions.
Meet Elveflow team all around the world 2018
Are you preparing a grant proposal (rise, fet, nmbp, eurostar…) under the horizon 2020 program? then partner with the biggest consortium of innovative and scientific smes in microfluidics to maximize the outcome of your project!
The OB1 MK3+ comes with different levels of warranty offers associated, and an out-of-warranty maintenance offer.
European Fellowships are held in EU Member States or Associated Countries and are open to researchers either coming to Europe from any country in the world or moving within Europe.
NBIC AND ANTI-AGING RESEARCH PROJECTS Setting up the French Microfluidic Valley through innovative start-ups is the goal of the Elvesys Microfluidic Innovation center
At Elveflow Accessories, we understand those issues and we try to help people work with this indecision, so we have a very special service that you are able to use.
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Syringe pumps are among the most used systems to handle fluids in microfluidic devices and chambers. For better performances, reproducible results and enhanced user experience choose the latest OB1 piezo-resistive technology !
Based on its aeronautic piezoelectric technologies, Elveflow pressurized syringe pump provide you the world most accurate flow controller for your cell biology researches. This perfusion system dedicated to cell culture includes all the necessary elements to create a continuous flow and monitor flow rate applied on your cell culture in real time .
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Elveflow Organ-on-chip microfluidic research project : We created the Elveflow Microfluidic innovation center because we believe that microfluidics is a key element of medical research tomorrow.
This pump is a robust device particularly fitted to vacuum filtration, desiccation, degassing, and other mid-range vacuum applications. If you feel that your research can benefit from this new tools, do not hesitate to contact us and discuss with our team of specialists!
MICROFLUIDICS is nowadays more and more used for cell biology. Indeed, the micrometer scale of microfluidic devices is particularly adapted to work with the size of cells, and miniaturization of the systems allow to easily implement high throughput assay. You become enable to study single cell or really rare component such as cancer cells, you reduce the volume of your sample and increase the research possibilities.
Get a surface pro 4 with our microfluidic instruments
In chemistry, life sciences and biotechnology research laboratories, clean compressed air is required in many protocols for various tasks such as filtration, degassing, distillation and many other operations such as cleaning silicon wafer using blowguns. Here are some key features points to consider when comparing compressors.
In modern research laboratories, oil-less compressed air is needed from a number of lab purposes from filtration, degassing, distillation and many other operations such as cleaning silicon wafer using blowguns. Here are some key features points to consider when comparing compressors.
Elveflow offers to researchers the possibility to test new products and to shape the developments of this new technology. If you feel that your research can benefit from this new tools, do not hesitate to contact us and discuss with our team of specialists!
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From the development of qPCR detection kits to the industrialization of microfluidic sample pre-treatments, we have all the know-hows to bring research consortiums closer to the target application.
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A PDMS PUNCHER, often described as "biopsy punch" - is a reusable, disposable tool used to drill clean holes in PDMS chips to enable tubing to chip connection. Therefore, you have to know the OD of the element (TUBING, steel coupler) you will use to connect to your chip.
Elveflow accesories migrate to a new online reseller
This heater cooler enables you to control the temperature of your sample in seconds during live cell imaging.
DNA microarrays have be widely used for molecular biology research. The microfluidic hybridation methods allow to reduce the volume of reagent and the time of incubation. See how our Injection Platform can help you design and achieve groundbreaking experiments.
Microfabricated devices allow performing enzymatic assays while using less reagent. See how our INJECTION PLATFORM can help you design and achieve groundbreaking experiments.
The new version of ESI software enable you to load your own data files in order to obtain customized pressure or flow profiles. CSV or tab-separated files (easily exported from a spreadsheet processor) can be used.
Whatever your setup, scientific instrumentation should remain Plug and Play. The ELVEFLOW® TEAM will gladly counsel you on the right solutions for your microfluidic flow control and plumbing issues so that you can focus on your research. Elveflow® is a company created by a team of former researchers in microfluidics. We focus on the development of high performance, Plug and Play flow control systems fitted to the needs of microfluidic researchers.
In cutting-edge research laboratories, clean vacuum is needed for a lot of lab applications from filtration, degassing, distillation and many other processes such as cleaning silicon wafer using blowguns. Here is what you will get if you purchase this kit:
In research facilities nowadays, oil-less vacuum is needed for a variety of lab purposes from filtration, degassing, distillation and many other operation processes. Here are some key features points to consider when comparing compressors.
Settling time of the flow rate and transient period can vary from several seconds to hours depending on the fluidic system.
To control future infectious disease outbreaks, like the 2014 Ebola epidemic, it is necessary to develop ultrafast molecular assays enabling rapid and sensitive diagnoses. To that end, several ultrafast real-time PCR systems have been previously developed, but they present issues that hinder their wide adoption, notably regarding their sensitivity and detection volume. An ultrafast, sensitive and large-volume real-time PCR system based on microfluidic thermalization is presented herein.
Feed & image your cells without interruption during 3 weeks
You wrote elevesys elesys, lvsys or LV6 you may search for Elvesys microfluidic innovation center You are not lost, you have just done a mistake writting Elvesys. We hope that this page will help you find your way in our website. And of course if you have any question feel free to contact us.
You wrote eleveflow, eleflow, lvflow or elveflo, you may search for ELVEFLOW microfluidic flow control system. You are not lost, you have just done a mistake writting elveflow. We hope that this page will help you finding your way in our website. And of course if you have any question feel free to contact us.
Equinox gathers really tough tools and almost none maintenance is required. The pressure control is guaranteed thanks to an electro valve that can handle 250 million of cycles and thus promises a long life time. The only maintenance operation is to change periodically the air filter if you use ambiant air such as gas.
Need microfluidics for your research ? We have a setup for your application
KNOW THE REAL FLOW RATE YOU ARE APPLYING. Based on our review 83% of researchers do not work at the right flow rate on their cells.
We are one of the few companies in the world that integrates all the knowledge and practices necessary to ensure the success of a microfluidics R&D partnership. Our core interest is to participate in research consortia linked to microfluidics in order to secure the development of research projects in the field of lab on a chip.
We provide a simple solution enabling to know the real flow rate delivered by any type of fluid handling systems.
A microfluidic connection (often seen as microfluidic interconnection) refers to the act of connecting microfluidic elements or their state of being connected.
These systems for cell culture consist of a gravity, bath perfusion system. When coupled with valves the system can be manually programmed, without requiring a computer or computer controlled.
Microfluidic Sleeves are basically diameter size adapters consisting in small pieces of tubing in which a smaller tubing is inserted. In order for small OD tubings to be compatible with fittings designed for larger OD sizes, microfluidic sleeves can be very helpful. The aim is to increase the OD of the inserted tubing to make it fit properly into a receiving port designed for larger tubing, e.g. when working with 1/32 OD microfluidic cappillary tubing and 1/4″-28 threaded connectors designed for 1/16 OD tubing.
The FluoBox is a fluorescence reading system designed for microfluidic applications. Faster, more sensitive and more cost effective than most optical microscopes, it is an advantageous alternative for real time fluorescence measurements of your on-chip qPCR signal. It offers a compact and cost effective alternative compared to high NA, low magnification objective epifluorescence microscopes.
Q: Do you have a step-by-step guide to help me set up my experiment? Yes, you can find tutorials, tips and guides in our basic section and our application notes section. You can also check the User Guide available in the USB key you have received with your equipment to obtain objective information about how to prepare your setup.
Microfluidic connectors are used to connect your microfluidic device or your lab-on-a-chip to external elements such as pressure & flow controllers and microfluidic reservoirs with rigid or softer microfluidic tubing.
This section of the Elveflow website gives the opportunity to researchers in microfluidics to publicize their last results presented on scientific conferences. Since a part of the scientific results presented during microfluidic conference are not published they remain lost for the scientific community.
23G hypodermic needles and steel adapters are commonly used with tubings to inject or extract liquid samples. They are described by gauge numbers indicating outer diameters (OD). Among those values, the 23-gauge (23G) is a standard in both Medical and Microfluidic fields. With a "23G fitted tubing" the sizes of tubing & needle fit, so that the 23G needle can be smoothly inserted into the 1/16" microfluidic tubing. Elveflow provides 1/16" OD MICROFLUIDIC TYGON TUBING 23G FITTED and 1/16" OD MICROFLUIDIC PTFE TEFLON TUBING 23G FITTED in the MICROFLUIDIC ACCESSORIES SHOP.
Certainly one cannot not mention the old and reputable LABORATORY OF MICROFLUIDICS AND NANOFLUIDICS of O. Vinogradova in Moscow State University which could be considered as a pioneer in microfluidics in Russia. New experiments will start in ALEXANDER GABIBOVS’ LABORATORY of Biocatalysis in Moscow Academy of Science as well.
1/16" tubing is used to connect your microfluidic LAB-ON-A-CHIP to the various components of your microfluidic setup. 1/16" refers to the Outside Diameter (OD). Elveflow provides 1/4 28" MICROFLUIDIC FITTINGS and 10-32 MICROFLUIDIC FITTINGS
Chemical control of the environment of cells is crucial for cell biology. Microfluidics enables to control chemical environment around cells with an higher spatio-temporal resolution than conventional gradient generator. Chemical gradients generated with microfluidic device can be changed in seconds and can reach sub-cellular resolution.
Microfluidics in Brazil is a fast-growing research field, as highlighted by the Microfluidics Workshop organized in the past years at the BRAZILIAN CENTER OF RESEARCH IN ENERGY AND MATERIALS (CNPEM). Research groups are already references in their fields. The Institute of Chemistry of São Carlos (IQSC) is one of them. The IQSC is the host of an exchange program in which students from Texan and Californian universities (UTSA and CSULA) receive an intensive training in Microfluidic Analytical Chemistry and participate in real Brazilian research projects.
Fluorinated ethylene-propylene tubing or FEP tubing is a nice alternative to PTFE TEFLON TUBING and PFA tubing that exhibits many similar properties such as biocompatibility and a remarkable inertness to most chemicals. This flexible material with very good optical clarity, is mostly used for low-pressure microfluidics. Its melting point is 205°C. You can find FEP SLEEVES IN OUR MICROFLUIDIC 1/32 TO 1/16 PTFE CAPILLARY TUBING & SLEEVES KIT.
Elveflow® USB microfluidic flow switch enables fast switching of flow in capillaries and microfluidic systems (patent pending). It contains an array of flow switches plugged in a microfabricated manifold to increase flow changes speed and reduce dead volumes.
The elasticity and high flexibility of Tygon tubing make it fit tightly to glass and metal and also be a chosen material for PDMS devices connections. It is very often used with sample reservoirs and analytical instruments such as pressure controllers, peristaltic pumps, vacuum pumps, or flow switch matrices. Tygon Tubing is available in our Microfluidic Shop.
PerFluoroAlkoxy, often described as Teflon-PFA tubing is a transparent, high-perfomance, melt processible and chemically inert Fluoropolymer that exhibits similar characteristics to PTFE. Its melting point is at 250°C.
PTFE TEFLON® TUBING (PolyTetraFluoroEthylene, often described as TEFLON® TUBING) is a transparent, chemically inert and non-toxic material that features unmatched chemical resistance and a surface that really facilitates the flow. Due to its high flexibility, PTFE is mostly used with MICROFLUIDIC FITTINGS in low-pressure applications. Its melting point is reached at 327°C, making it a material of choice in high temperature applications. This very popular element is available in our MICROFLUIDIC ACCESSORIES section.
PEEK Tubing (PolyEtherEtherKetone or PEEK) is a biocompatible and very chemically compatible material widely described as the highest performance thermoplastic material currently available because of its remarkable chemical resistance. However, due to a swelling effect, be cautious in using methylene chloride, THF, and DMSO. Nevertheless, these qualities make PEEK MICROFLUIDIC TUBING and PEEK FITTINGS elements of choice in numerous low and high pressure applications.
Tubing is a particular kind of MICROFLUIDIC ACCESSORIES generally used to transport small volumes of liquids from a MICROFLUIDIC GLASS RESERVOIR, A MICROFLUIDIC EPPENDORF ADAPTER OR MICROFLUIDIC FALCON TUBE ADAPTER to a microfluidic chip. The liquids coming from these reservoirs are generally pressurized by Pressure Controllers, using larger tubings. Just like wires in electronics, MICROFLUIDIC TUBINGS are used to link the multiple parts of your microfluidic setup. It is charaterised by the inner and outer diameter (ID and OD) and wall thickness (WT). This element has its own dedicated kit available in our MICROFLUIDIC TUBING ACCESSORIES section.
Generate and control pressure for your microfluidic chip without the installation of comprimed air lines or air compressors. Elveflow® pressure sources allow the installation of a microfluidic experiment in a few minutes on any lab bench equiped with an electric plug.
Microfluidic adapters are small MICROFLUIDIC ACCESSORIES that make it possible to establish a connection between two fittings with different thread values, enabling to connect for example ¼-28 THREAD with 10-32 THREAD fittings.
For the first time get a high precision pressure controller and a pressure source in the same equipment
Elveflow® high precision suction pump generates and regulates negative pressure down to -600mBar ( -8.7 psi ) with a precision of 1mBar ( 0.0145 psi ). It can be used for a wide range of applications requiring aspiration such as cell manipulation using micropipette, patch clamp or microfluidic flow control using aspiration.
Elveflow® OB1 pressure controllers are compact and customizable systems designed to generate a stable and pulseless flow and control independently up to 4 channels, for a wide variety of challenging microfluidic applications. MORE INFO
HPLC (High-Performance Liquid Chromatography) is an analytic chemistry technique used to separate, identify and quantify each component of a mixture. While the aim of this short note is not to make some kind of historical background of this field, it is important to know that HPLC is largely the origin of the major advancements concerning MICROFLUIDIC FITTINGS. HPLC fittings are used very broadly to connect the various elements (PRESSURE CONTROLLER, sample reservoirs, etc...) of a microfluidic setup.
A wrench tight fitting has a head geometry that can be properly tightened with a wrench. It is important to specify the diameter from flat to flat side of the head to use the correct wrench. The 2 mostly used wrench tightening geometries are the Hex-head and the wrench flat.
Elveflow® high accuracy vacuum source - Control fluid’s flow into microfluidic chips
A fingertight fitting has a head geometry that allows very fast tightening or removal using your fingers. The most popular fingertight head geometries are the Knurled-head and the Winged head.
For the first time, get a high precision vacuum controller and a vacuum generator in the same equipment.
A head geometry is an important feature of a nut used in the tightening process to a receiving port (e.g. knurled, hexagonal, square). The Head geometry is typically composed of two classes, the FINGERTIGHT FITTINGS and the WRENCH TIGHTENING FITTINGS.
Accurate pressure regulator with embedded pressure pump
Flat VS coned FITTINGS can be distinguished according to the type of port concerned : coned or flat-bottomed. With coned fittings, the tapered nose of the ferrule is pressed against the base of the receiving port bottom, whereas with flat-bottom fittings, the tapered nose is pressed against the nut while the flat side latches securely in place against the port bottom.
We know that biochemistry and molecular biology assays are very demanding. Whether you need to inject several samples and buffers, or you need to expose your probe to a sample with a precise timing, you need a full control over your experiment conditions.
A receiving port is an element designed to receive a FITTING, and it is described by a thread size that has to be the same as the nut's one. When choosing MICROFLUIDIC ACCESSORIES, you have to know the bottom geometry of the port to choose the appropriate ferrule.
A Nut is the biggest part of a fitting and the most common MICROFLUIDIC ACCESSORY. It receives the tubing and the ferrule and is tightened to the receiving port to seal it. To choose the right nut, you have to know the thread of the receiving part and the OD of the tubing.
A microfluidic flow control system which allows flow switch in less than 1 second.
A ferrule is the smallest part of a microfluidic fitting, designed to be deformed by screwing the nut into the receiving port. By doing so, it blocks the tubing inside the nut and seals the port to the tubing. To choose the right ferrule, you have to know the design of the receiving port's bottom (flat-bottom port, coned port, etc...).
As a consequence, a syringe pump or a peristaltic pump can establish a stable flow rate in an elastic tubing environment; but it will result in long equilibrium times. On the other hand, using a syringe pump with rigid tubing will result in shorter response times; but important pulsations will appear due to mechanical hysteresis.
A fitting is an element composed of a nut and a ferrule that are specifically designed to fit together. Fittings are most of the time screwed to receiving ports. When it's locked in, the ferrule seals the tubing to the nut which is itself hermetically sealed to the port. Two fittings might have the same thread, but different port geometries, OD tubing diameters or Head geometry. Though Fittings are intended for high-pressure connections, they are usually also used in LOW PRESSURE MICROFLUIDIC APPLICATIONS.
Flow Injection Analysis (FIA) is a branch of chemistry that consists in injecting a chemical sample at low flow rate - several milliliter or microliter per minute - into a major stream of another reagent. After going through a coiling reactor, products analysis is operated by different techniques such as UV spectroscopy, chromatography, ion-selective electrodes or biosensors.
For any help to determine what microfluidic instruments you need, you can contact us! Our experts will help you build the best microfluidic setup for your application, with our state-of-the-art microfluidic line.
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