SET-UP TIME : 10-15 MIN / DIFFICULTY : *****
This application note describes:
It has been realized at the millifluidic scale. Chromatographic Teflon T-junction and capillary tubing are used as channels of the device. To generate droplets in a microfluidic capillary, the following features are key:
The flow rate was finely controlled with the OB1 MkIII pressure-driven flow controller. The piezoelectric technology used to perform pressure regulation allows great flow accuracy & ms response time.
Droplet generation is employed for many application from as emulsion production, single cell analysis, drug delivery, to polymer beads or nanoparticles synthesis.
The following illustrates the complete chain of the elements involved in this application note. You will need to assemble all these parts to set up your experiment and generate controlled size droplets while using the Elveflow® smart interface.
Flow controller
Flow sensor
Reservoirs
Tubing
Fittings
T-junction
Here is a short video presenting the working principle of Elveflow piezoelectric technology employed to perform pressure-driven microfluidic flow control for your experiment!
A) Monitoring the pressure to generate controlled size droplets:
The Elveflow® smart interface allows to control pressure for the oil and water samples.
One can also program sequences in order to generate droplet streams, oil plugs of controlled sized etc.
B) Monitoring the flow rate to generate controlled size droplets:
When coupled with Flow Sensors our controller enables to control the flow rate thanks to a PID feedback loop. One can request the flow values in the Elveflow® smart interface and the pressure controller will adjust the pressure consequently to reach the requested values.
Congratulations! You’ve achieved the generation of controlled-size droplets in a microfluidic capillary using an Elveflow® Flow sensor and the Elveflow® pressure control instrument!
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Do you want tips on how to best set up your microfluidic experiment? Do you need inspiration or a different angle to take on your specific problem? Well, we probably have an application note just for you, feel free to check them out!
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