MOP – Microfluidic Organ-on-chip Pack

Ideal to mimic physiological conditions

For imaging cell’s response to various media or drugs

Fine control over quantity delivered

From 0.01 µL/min to 5 mL/min

Create complex patterns, such as oscillating flow to mimic physiological conditions

Elveflow has joined forces with ALine Inc. which has a proven track record in the area to provide among different options a microfluidic chip designed for cell culture. Two independently accessible chambers are separated by a porous membrane of choice. Unlike microtiter plate based systems, these devices allow continuous flow in one or both chambers. Balancing the pressure drop across the membrane can be used to adjust the flux across the membrane.

Aline Inc has also the ability to carry your design from prototyping through development to manufacturing. Their expertise throughout the development stages enables us to ensure your design is manufacturing ready from an early stage, eliminating scale-up issues that so often plague technologies. In addition to microfluidic chip design, they have extensive experience in integrated functional solutions, such as the incorporation of electrodes, membranes and valves, integration with sensors, printed circuit boards and blister packs, and reagent deposition.

The pack can be used either with the chip from Aline Inc, your homemade chip or any other commercial solution available

One can use our MUX Inj to perform a unidirectional flow circulation to ensure cell nurturing over days

One can detect potential bubble in the setup and setup an action accordingly through the software

Possibility to use one or several pressure sensors to measure the pressure drop accross the system

Organs-on-chips not only has the advantages such as miniaturization, integration and low consumption, but also it can accurately control the multi-parameters of system such a chemical concentration gradient, fluid shear stress, cell patterning, tissue-tissue interface, organ-organ interaction and so on, mimicking the complex structure, microenvironment and physiological function of human organs.

These applications hold the promise of having a significant impact on improving the predictability of drug screening models and Personalised Medicine. Organ-on-a-chip technology supports these research areas by providing an environment that can mimic the human physiology and morphology in vivo better than traditional cell culturing methods. Scalable organ-on-a-chip production is made possible by combining the enabling technologies originating from both the semiconductor and molecular biology industries.