Fully automate several days of experiment
Smooth, pulseless control of flow rates and flow directions of media
Full control of fluidic parameters in one or several parallel chips
User-friendly equipment with quick setup and intuitive software
Elveflow’s Organ-On-Chip Pack setup uses one flow controller to flow a medium through a chip containing the organ cells. The software allows a very accurate and stable control of the flow rate over defined periods of time.
Whether you want to add multiple fluidic channels, customize your microfluidic chip or add a vacuum control, our microfluidic specialists can customize the pack so that it can best fit your experimental needs.
Contact us for more information!
Organs-on-chips applications do not only have several advantages such as miniaturization, integration and low consumption, but also they allow researchers to accurately control the multiple parameters of a system such as chemical concentration gradient, fluid shear stress, cell patterning, tissue-tissue interface, organ-organ interaction and so on. They aim at mimicking the complex structure, microenvironment and physiological function of human organs.
These applications hold the promise of having a significant impact on improving the predictability of drug screening models and personalized medicine. Organ-on-a-chip technology supports these research areas by providing an environment that can mimic the human physiology and morphology in vivo better than traditional static cell culturing methods. Scalable organ-on-a-chip production is made possible by combining the technologies originating from both the semiconductor and molecular biology industries.
The Organ-On-Chip Pack can be used with any commercial chip or self-made chip.
ChipShop is a company offering versatile chips for several applications including 3D cell culture and organ-on-a-chip. Particularly, the cross flow membrane chip (Fluidic 480) enables to create a tissue interface to mimic organs functions (gut-on-chip, brain-on-chip, kidney-on-chip, skin-on-chip, etc.).This chip hosts two different culture chambers separated by a permeable membrane. Different cell types can be seeded on one or both sides of the membrane and exposed to dynamic flow conditions.
Microchip with 2 independant chambers for organ on chip studies
There are several chip designs available for organ-on-chips experiments, depending on the type of organs that scientists would like to mimic and the experimental protocols. Elveflow is working closely with several organ-on-chips providers to supply the most suitable chip for your science.
To help you determine your flow rate, pressure to apply, the best tubing resistance length for your setup, wall shear stress for biology applications, cell culture, and many more…
Elveflow provides its microfluidic calculator and…to make the most of our microfluidic calculator, find below a set of dedicated application notes:
A microfluidic circulatory system integrated with capillary-assisted pressure sensors
Lab on Chip, Y. Chen, H. N. Chan, S. A. Michael, Y. Shen, Y. Chen, Q. Tian, L. Huang and H. Wu, 2017
Bioengineered Human Organ-on-Chip Reveals Intestinal Microenvironment and Mechanical Forces Impacting Shigella Infection
Cell Host & Microbe, Alexandre Grassart et al., 2019
A Fast Alternative to Soft Lithography for the Fabrication of Organ-on-a-Chip Elastomeric-Based Devices and Microactuators
Science Advances, Daniel A. Ferreira et al., 2021
Elveflow’s expert in liquid actuation & flow control recommend the use of relevant chips such as the MesoBioTech solutions with these advantages:
“Elveflow provided an excellent solution to our problem, which was how to tightly control minute flows in multiple microfluidic channels.-”Dr. Robert Ward, Massey University, United StatesOB1 pressure-driven flow controller user
“We really appreciate the stability and low response time of the flow controller, which is important when various flow conditions must be applied successively. The flow can be precisely and easily controlled thanks to a user-friendly interface.”Dr. Marie Frénéa-Robin, Laboratoire AMPERE, Université Claude Bernard LYON 1, FranceOB1 pressure-driven flow controller user
The ESI software can control up to 16 Instruments through the same interface. Thanks to TTL triggers you can synchronize your Elveflow system with any other instrument used in your laboratory (microscope or any electrical instrument … ). The Scheduler is a user-friendly tool to automate complex steps of your experiments and protocols.
Enter your targeted volume and this module will automatically adjust the flow rate at the right time to inject it.
Automatic diagnostic of the fluidic path sizing and recommendations to improve your microfluidic setup.
Do not suffer anymore because of bubbles!
Don’t lose precious time in calibration protocols.
For any help to determine what microfluidic instruments you need, you can contact us! Our experts will help you build the best microfluidic setup for your application, with our state-of-the-art microfluidic line.
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