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OB1 MK3+

Flow Controller For 3D Model Perfusion

accurate flow and pressure controller for engineered tissue perfusion

Pressure control

Accurately push your medium at a controlled flow rate.

Low volume

Small pressure to reduce the volume of liquid.

Custom pressure profile

Reproduce the pulsatile flow of the blood or any custom pressure profile.

Parallelization

Increase your number of replicates to obtain statistically relevant results.

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Features & benefits

Cutting-edge microfluidic flow controller for perfusion of engineered tissues

3D tissue models are increasingly being used because they better replicate the physiology of the studied organ. In vivo, tissues are highly vascularized to ensure the supply of nutrients and oxygen to the cells. In vitro, alternatives must be found to prevent the formation of necrotic tissue within the model. In static culture, nutrient supply is ensured by diffusion which is limited to 100-200 µm. Constant perfusion of culture medium within a sufficiently porous 3D model is one of the alternatives to improve nutrient and oxygen access to the cells. Additionally, this technique also allows for varying the flow of medium to replicate pulsatile blood circulation. Designed by scientists for scientists, the versatile and powerful OB1 MK4 pressure controller provides the perfect perfusion control for your experiment.

Whether you need short or week-long experiments, stable or pulsatile flow, the OB1 MK4 flow controller is the ideal instrument for perfusing your in vitro 3D models.

Customizable & upgradable solution depending on your tissue model

The OB1 MK4 flow controller is configured according to your needs and your experiment. Depending on the number of media to perfuse and the number of chips, we can customize the flow controller to fit your requirements. For instance, you want to identify the best perfusion profile for your 3D heart model. With this instrument, you have the capability to tune the pressure profiles, allowing for a comprehensive assessment of the effects of perfusion on your 3D tissue model. The OB1 flow controller can be upgraded at any time according to your needs and experiment developments, in any way you want.

Control the shear stress applied to the cells

Under a flow, cells are submitted to shear stress due to the force that is exerted by the liquid on their surface. This shear stress is a key element to reproducing the physiology but might be dreadful for cells if it is not well controlled. By connecting the OB1 MK4 to a flow rate sensor (MFS) or our premium Coriolis flow sensor (BFS, for both liquid and gas), you can precisely measure the shear stress submitted by the cells. Additionally, our easy-to-use software allows you to control this shear stress over time.

Using our intuitive software, you can create a sequence of instructions to automate your experiments. A more advanced option consists in using the SDK libraries to control the OB1 MK4 using your own code while connecting it to other instruments.

Our cutting-edge microfluidic flow controller for synthetic cells studies can also be used for other applications such as:

Videos

Publications

For all the publications using our products, please click here.

For all the application notes and reviews based on our product, please click here.

This table summarizes the main specifications of the Elveflow® OB1 MK3 pressure controller. To provide quality & performance, all of our instruments are tested and calibrated independently (response time, stability, repeatability… ) after being assembled and all test results are kept.

Testimonials

“We are using the device extensively at the moment and I have been quite impressed by its capabilities”
Dr. Hayden Taylor, University of California, Berkeley, United States
OB1 flow controller user
“I found the systems quite robust and easy to connect and use”
Martino Chiara - deMello Group, ETH Zurich, Switzerland
Droplet pack user
“The OB1 is performing so well and we are very impressed by its behavior so far.”
Eric Pedrol Ripoll, Facultat de Quimica, Universitat Rovira i Virgili, Spain
OB1 flow controller user
“The Elveflow OB1 enables us precise pressure and flow control and measurement in various microfluidic and lab scale projects from tissue engineering to membrane filtration analysis. ”
Arne Lüken, Chemical Process Engineering at RWTH Aachen, Germany
OB1 flow controller user
“We are the proud owners of an OB1 we bought about a decade ago. It is still going strong. We would like to ask for a quote for another OB1.”
Dr. David Tadres, University of California, Santa Barbara
OB1 flow controller user
“After an easy installation, we are now using the OB1 and flow sensors routinely and are very satisfied by both the flow stability and the software's user-friendly interface.”
Nelson BC Serre and Matyáš Fendrych, Cell Growth Lab, Department of Experimental Plant Biology, Charles University, Czech Republic
OB1 flow controller user
“We have used Elveflow's products for about 9 years now and are big fans, and have made lots of recommendations to friends in Wageningen and the Netherlands. They are so easy to use, reliable and the pricing is sharp. We are very happy customers! ”
Prof. Dr. Joris Sprakel, Physical Chemistry and soft Matter, Wageningen university, Netherlands
OB1 flow controller user
“I've extensively used Elveflow systems in the World's most Brilliant X-ray source. Elveflow systems are precise, controlled and adaptive to many samples under adverse conditions.”
Pushparani Micheal Raj, PhD, Max Planck Institute of Quantum Optics, Lund, Sweden & MAX IV Laboratory, Bavaria, Germany
OB1 flow controller user
“We use Elveflow instrument in several projects and they are great to work with. The LabVIEW implementation was also very successful. I hope more people can get to know the OB1 system.”
Seongjin Park, Senior Engineer, Illumina
OB1 flow controller user

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Software

A free software for all instruments

Powerful, modular and versatile set-up control solution

The ESI software can control up to 16 Instruments through the same interface. Thanks to TTL triggers you can synchronize your Elveflow system with any other instrument used in your laboratory (microscope or any electrical instrument … ). The Scheduler is a user-friendly tool to automate complex steps of your experiments and protocols.

Volume
Injection
module

Enter your targeted volume and this module will automatically adjust the flow rate at the right time to inject it.

Fluidic system optimization module

Automatic diagnostic of the fluidic path sizing and recommendations to improve your microfluidic setup.

Bubble
detection
module

Do not suffer anymore because of bubbles!

Sensor calibration module

Don’t lose precious time in calibration protocols.

Need help or advice?

For any help to determine what microfluidic instruments you need, you can contact us!
Our experts will help you build the best microfluidic setup for your application, with our state-of-the-art microfluidic line.