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Development of a platform to engineer and optimize the behavior of biohybrid Active Matter

Microfluidic research project Elveflow industrial PhD Paris scaled
Active matter is a new field of interest at the boundary between material science, chemistry and cell biology. It designates particles that show life-like features. They can be made of components that are synthetic, biological or a mix of both. These so called micro-, and nanoswimmers can convert the energy from their surroundings in order to propel themselves and react to external stimuli to reorient or create complex self-organized structures. Studying active matter could lead to a better understanding of far from equilibrium physics and the dynamic that is at the origin of living organisms.
Many different propulsions mechanisms exist and are studied to reproduce the behavior of active matter. Most of the time it involves the catalytic degradation of a fuel (i.e. hydrogen peroxide) that creates a local electrolyte gradient that drives the particles. In other systems, the propulsion is initiated by living cells such as bacteria or sperm cells that can be conjugated with inorganic particles. In any case, many challenges remain before including these systems into real applications. For example, avoid the use of toxic fuels and increase the biocompatibility. What is also lacking in most experiments is the presence of an external flow and boundaries around the particles that can affect the behavior of the active matter.
Microfluidic systems are very powerful tools for performing flow and chemistry experiments. With its precise pressure controllers and flow sensors, Elvesys has the perfect set up to develop a microfluidic platform for the study and characterization of biohybrid active matter. The microfluidic device will allow to investigate the behavior of different types of biological microswimmers, i.e. various species of sperm cells, under flow conditions. Sperm cells’ motion is influenced by the topology of their surroundings, as well as chemical, thermal or viscosity gradients. This project aims to take a step closer to real life settings with the use of active matter such as drug delivery, assisted reproduction techniques, sensors, etc.
Active Matter microfluidic droplet Microswimmer
Example of a particular inorganic microswimmer made of platinum and gold which is self-propelled in presence of hydrogen peroxide. Image source: Paxton, W. F., et al, Journal of the American Chemical Society, 2006, 128(46), 14881–14888. https://doi.org/10.1021/ja0643164
This project has received funding from the European Union’s Horizon research and innovation program under the Marie Sklodowska-Curie grant agreement No 812780 (ActiveMatter project).
Active Matter microfluidic droplet Elvesys Audrey scaled

RESEARCHER

Audrey Nsamela

PhD candidate Elvesys/Dresden University of Technology

  • Master of Applied Science in Biomedical Engineering (Ecole Polytechnique Montreal, Canada)
  • Master in Physics Engineering, oriented fundamental physics (Université Catholique de Louvain, Belgium)
  • Bachelor in Engineering science, oriented applied physical chemistry and biomedical engineering (Université Catholique de Louvain, Belgium)

AREAS OF EXPERTISE: 

physics engineering, biomedical engineering, nanotechnology, surface functionalization, cell biology, immunoassay, in-vitro diagnostics, microfluidics, polymers.

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