Home / Application-based use cases / Microfluidic liquid-liquid extraction
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MICROFLUIDIC LIQUID-LIQUID EXTRACTION

Use case

Extract a compound from solvent “a” to solvent “b” under continuous flow
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Tailored throughput solutions

Whether you need low or high throughput, our system supports flow rates from 100 µL/min to 100 mL/min and beyond.

Precision control with minimal sample use

Achieve precise flow regulation with minimal sample consumption, powered by our OB1 flow controller.

Scalable automation for complex applications

Effortlessly automate multi-step processes to enhance performance and efficiency as your needs evolve.

Seamless scale-up for large-scale extraction

Easily scale your extraction process from microliters to liters without hassle.

A microfluidic beginner instrument use case for liquid-liquid extraction

Our versatile liquid-liquid extraction setup is designed to cover a wide range of applications. The system is built around the fast and accurate pressure-driven OB1 flow controller (Elveflow), which precisely injects the two working solutions at a predefined ratio.
  • Flow rates can be monitored and regulated thanks to Elveflow BFS flow sensors.
  • Additional fluidic resistances can be added to achieve high flow stability and accuracy.
  • The size of the reservoirs is customizable depending on your needs – from 1.5 mL tubes to 1 L bottles.
  • Allow an extraction without a phase-shifting step or a separation phase.
  • The system is well-suited for research purposes and industrial scales, thanks to parallelization.
The system is perfect for determining the operational conditions of liquid-liquid extraction; with the small volume required, quick experiment run, and high efficiency, you can test several solvents, ratios, and residence times to optimize your protocol. To help you get started immediately, our team of specialists will assist in setting up your microfluidic platform and provide beginner-friendly advice and user guides. Moreover, different chips can be used with your setup. In the example below, the Fluidic 912 from Microfluidic ChipShop generated micrometer-sized droplets to increase the surface-to-volume ratio.

Comprehensive liquid-liquid extraction setup

Tailor your microfluidic chip design to fit your unique application and reaction kinetics. We offer expert guidance on selecting third-party chips or provide you with the tools to fabricate your own custom chips.

Our all-in-one liquid-liquid extraction setup is designed to meet your needs, ensuring seamless integration and optimal performance.

Setup-for-Liquid-Liquid-extraction

The liquid-liquid extraction USE CASE contains:

  • OB1 flow controller (Elveflow)
  • Flow (Elveflow)
  • Several Falcon reservoirs 
  • Tubings and fittings 
  • Microfluidic chip of your choice
  • ESI software (Elveflow)

Explore versatile microfluidic liquid-liquid extraction applications

  • Organic compound separation: Efficiently extract caffeine from coffee beans or purify essential oils.
  • Metal recovery: Recover valuable metals like copper from waste streams with precision.
  • Rare-earth element purification: Achieve high-purity separation of rare-earth elements.
  • Impurity removal: Effectively eliminate trace water from organic solvents or toxic impurities from industrial effluents.
  • Biofuel production: Extract biodiesel from vegetable oil for sustainable energy solutions.
  • Isomer separation: Precisely separate cis- and trans-isomers of compounds.
  • Environmental cleanup: Remove harmful polycyclic aromatic hydrocarbons (PAHs) from contaminated soil.
  • Food industry applications: Extract natural vanilla flavor from beans with high efficiency.
  • Analytical chemistry: Accurately extract drugs from blood or urine samples for reliable analysis.
  • Biotech advancements: Purify enzymes or antibodies from cell culture media for cutting-edge research.
Discover more in our recent review of integrated microfluidic liquid-liquid extraction systems, highlighting their benefits and key applications.
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Design of the chip

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Microfluidic ChipShop chip fluidic 912
detail of the microfluidic chip

Customize your liquid-liquid extraction setup

Whether you need instruments compatible with standard commercial chips from top brands or a comprehensive platform to produce your own PDMS chips, we’ve got you covered. Tailor this package to your exact requirements, with expert guidance from our specialists to ensure you select the ideal setup. – Explore our other use cases for a wide range of applications –

MICROFLUIDIC LIQUID-LIQUID EXTRACTION

Use case

Extract a compound from solvent “a” to solvent “b” under continuous flow
Talk to an expert

Tailored throughput solutions

Whether you need low or high throughput, our system supports flow rates from 100 µL/min to 100 mL/min and beyond.

Precision control with minimal sample use

Achieve precise flow regulation with minimal sample consumption, powered by our OB1 flow controller.

Scalable automation for complex applications

Effortlessly automate multi-step processes to enhance performance and efficiency as your needs evolve.

Seamless scale-up for large-scale extraction

Easily scale your extraction process from microliters to liters without hassle.

Talk to an expert

Features & Benefits

Need help or advice?

Contact us for expert help in microfluidics!

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