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Molecular and cellular medicine UKRI Grant

 

UKRI MRC Grant: Molecular and Cellular Medicine

Empower Your Project with Microfluidics

The Medical Research Council (MRC) is funding projects focused on cutting-edge fundamental and translational research to accelerate diagnosis, advance treatment, and prevent human disease. They are launching a funding opportunity on Molecular and Cellular Medicine, which opened in May 2025 and closes on the 4th of September 2025. This call is funding research including areas such as regenerative medicine, cell biology, structural biology, cancer, toxicology, and pharmacology.


There is still time to apply, and we would be happy to help you define your microfluidic needs to empower your application!


If you are considering applying for this call for projects, Elveflow instruments could be a valuable asset. At Elveflow, we help you bring precision and control to your experiments with pressure-based microfluidics. With 15+ years of experience in microfluidic flow control, Elveflow provides high-performance instruments trusted by academic researchers across the world for their molecular and cellular biology projects.

What is Pressure-based Microfluidics?

Pressure-based microfluidics is a method of controlling fluid flow by applying precise pressure differentials rather than using mechanical pumps like syringes or peristaltic pumps. Instead of pushing a known volume of liquid (as in flow-rate-based systems), pressure-based systems apply a set pressure to a fluid reservoir.

Fluid injection in a microfluidic chip using a pressure-driven system

Example of fluid injection in a microfluidic chip using a pressure-driven system (OB1)

Pressure-based microfluidics offers several advantages, including millisecond-scale response times, highly stable and pulseless flow, compatibility with automation, and sensor-based feedback loops. It also ensures a gentle handling of samples without the mechanical stress associated with syringe pumps or peristaltic pumps.

At Elveflow, we provide a precise, stable, and responsive fluid handling controller that can accurately reproduce a wide range of flow profiles. Associated with a flow sensor, you can efficiently monitor and control the flow rate with unmatched precision. Whether you need a constant and very stable profile, a pulsatile profile or a customized profile, the instrument adapts to your needs and gives you complete control over your experimental parameters (shear stress/volume injection, etc.) as well as the ability to reproduce physiological conditions. Including the Piezoelectric technology, this pressure controller gives you 20 times more precise and 10 times faster flow control than any other flow controller on the market: your cells are in good hands!  

ESI pressure profile

Multiple pressure profiles available in Elveflow Smart Interface (ESI) 

Our product line also includes rotary valves for distribution and sequential injection or media recirculation, a set of on/off and 3/2 valves, various sensors (flow rate, pressure, bubble), sensor readers, and all essential accessories such as bubble trap, tubing, fittings, and manifold. The Elveflow range of instruments is versatile and intended for a wide array of biological applications.  

Why Choose Elveflow for Your Project?

1. Get started with Dynamic Cell Culture

Recreate physiological conditions for cell-based assays using our OB1 Pressure Controller and perform accurate and stable long-term control of microenvironments using our MUX Recirculation Valve. Elveflow’s pressure-based flow control systems offer a reliable solution, with accurate temporal stability and responsiveness, making them especially suitable for extended biological experiments.

Check out our application note on Dynamic cell culture!

2. Bring your Organoids and Organ-on-a-Chip to the next level

The development of Organ-on-a-Chip (OoC) technology has opened up new possibilities for studying pathologies specific to humans that cannot be reproduced in animal models. OoC platforms mimic the microarchitecture of organs while introducing essential elements such as flow and peristalsis. The OB1 pressure controller is the perfect instrument to control the flow on OoC and reproduce different flow profiles with great accuracy to mimic as much as possible the physiological conditions. 

Check out our research summary presenting a study on gut-on-chip and pathogen invasion!

3. Improve your diagnostic tools and therapeutic strategies

The challenge of developing diagnostic tools and new therapies has never been more important than it is now. Microfluidics is the tool of choice for meeting this challenge as it can minimize manual steps and reagent consumption, optimize sequential injection while enabling the development of compact devices that precisely control physicochemical reactions. Elveflow instrumentation participates actively by optimizing flow control, in particular with our MUX Distribution valve, for the development of immunoassays or for studies on antimicrobial resistance. 


Check out this research summary on the integration of immunoassay technologies, as well as this interview exploring bacterial adaptation
!

4. Push the boundaries of tissue models and regenerative medicine

Tissue engineering is a subject that has been developing steadily since the 1980s. Our participation in the conference TERMIS EU 2025 allowed us to see how valuable our instruments are in this field because of their versatility and robustness. They can adapt to a wide range of research studies, from vascularization strategies through dynamic flow and growth factor gradients, to the replication of complex physiological barriers like the blood-brain interface. 


Check out how the OB1 pressure controller integrates in this research on myocardial ischemia
!

5. Optimize your droplet generation

The Elveflow’s instrumentation, and especially the droplet generation pack, is ideal to create highly monodisperse droplets and perform single cell encapsulation or controlled emulsions. This pack can be adapted to answer various needs and fit various applications, such as:

  • Gene expression profiling
  • Single-cell sequencing
  • Single-cell encapsulation
  • Microgel synthesis
  • And many more! 

Check out this application note on sequential production of droplets or this one on single spore encapsulation to better understand the process!

Let’s Make Your Proposal Stand Out!

Adding a microfluidic setup to your grant proposal justify your care for precision and reproducibility. Our instrumentation will help you: 

  • Reproduce physiological conditions 
  • Perform accurate and long-term experiments
  • Control accurately the shear stress and other experimental parameters  
  • Automate toxicology testing using specific valves for sequential injection 
  • Optimize your cell encapsulation efficiency

Our team of experts will help you:

  • Identify the right Elveflow tools for your project.
  • Provide documentation to strengthen your grant application.
  • Get training and support during your project to ensure smooth implementation in your lab.

We are available to answer any microfluidic questions you may have when submitting your project. Our microfluidics experts can help you define the ideal microfluidic system configuration. 

Please note that the submission deadline is September 4, 2025 at 4pm: don’t wait to contact us to consolidate your project.

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