Easily culture and monitor over 20 spheroids at once with our microfluidic platform, allowing for high-throughput experiments with precise control.
Enjoy continuous, automated perfusion for days, ensuring your spheroids receive consistent nutrients and shear stress, closely mimicking in vivo conditions.
Our dynamic perfusion system replicates real-life physiological conditions more accurately than static cultures, leading to better models for studying cell behavior and drug responses.
Beginner-Friendly Microfluidic Platform for Spheroid Culture
Spheroids, which are three-dimensional cell clusters, offer a more realistic representation of cell interactions and behaviors within the human body compared to traditional 2D cultures. By utilizing microfluidic technology, you can enhance reproducibility, control shear stress, optimize pH and temperature, and reduce the volume of costly reagents needed.
Our platform is designed to be user-friendly, even for those new to microfluidics. It includes high-precision instruments like the OB1 flow controller (Elveflow) and flow sensors that work seamlessly with either custom-made or commercially available microfluidic chips.
The microfluidic platform we provide is optimized for spheroid growth under well-controlled conditions. This plug-and-play solution is ideal for researchers looking to transition from traditional static cultures to more dynamic and accurate microfluidic systems. The platform’s automation capabilities allow for improved reproducibility and efficient use of samples.
The Elveflow OB1 MK4 flow controller, paired with Galileo flow sensors, offers precise, pulseless flow control, crucial for mimicking in vivo conditions by accurately applying shear stress to cells. This setup is the most stable and precise microfluidic solution available, outperforming conventional syringes and peristaltic pumps.
For long-term experiments, such as those involving spheroid cultures, medium recirculation is essential. Our system allows for consistent shear stress without the need for large volumes of expensive medium. Additional components like a MUX recirculation system or a MUX distribution valve can be integrated to introduce different media and drugs during your experiments.
Spheroid Cell Culture Components
A typical spheroid cell culture setup includes:
Spheroids, as 3D cell structures, more accurately replicate cell-to-cell interactions and the in vivo environment compared to monolayer cultures. They are particularly valuable in cancer research as tumor models but are also useful for studying other diseases, such as neurodegenerative conditions.
Microfluidic technology enhances spheroid culture by providing controlled shear stress, reducing reagent use, and allowing for long-term, automated experiments. This method has been successfully employed in drug screening, leading to more precise and reliable results while reducing reliance on animal models.
Culturing spheroids in a microfluidic environment offers several key benefits:
These advantages make microfluidics the preferred method for spheroid culture and drug screening, offering the best combination of precision, user-friendliness, and cost-effectiveness.
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