Easily create microspheres using a variety of PVA polymer solutions.
Achieve high-speed control of flow rates for increased production frequency.
Benefit from precise control with real-time monitoring and feedback.
Scale up your process effortlessly, from microliters to liters.
This setup integrates advanced flow control technology with commercially available or custom-made microfluidic chips, enabling the production of PVA microspheres with precise size and distribution. It’s an ideal solution for complex applications such as medicine, tissue engineering, and drug delivery.
Microfluidics offers unparalleled control over flow and pressure, crucial for producing PVA microspheres with precise bead size and consistent particle monodispersity. Traditional methods often lack this level of control, resulting in poor dimensional accuracy.
With microfluidics, you gain precise control over particle generation, leading to better size consistency, reproducibility, and scalability while reducing waste. Our pressure-driven flow control system, featuring Elveflow’s OB1 flow controller and flow sensor, automates and fine-tunes the microsphere formation process by continuously monitoring and adjusting flow rates and pressure in the microchannels.
This setup ensures you can reliably produce PVA microspheres with the desired characteristics, leveraging their biocompatibility, low cost, and chemical stability. Ideal for a variety of PVA polymer solutions, microfluidics enables high-precision production with minimal waste and easy scalability for industrial-scale applications. Plus, the OB1 system accelerates the production process compared to traditional methods.
Looking to customize your PVA microspheres? This setup allows you to explore various configurations and achieve the precise microspheres you need.
If you require further customization, start by designing your microfluidic chip. Key considerations include the amount of input substances and the shape of the junction where these substances will interact to form the microspheres. For detailed guidance on designing your chip or microfluidic system, see the specifications provided.
Once you’ve defined the critical parameters for your research, you can adapt your microfluidic device accordingly.
Model N° 1: For this configuration, the necessary solutions include:
Microsphere generation begins on the chip, where PVA/GA hybrid droplets form at the microchannel junction. These droplets are mixed in a serpentine-shaped channel to enhance mixing efficiency. The mixture then undergoes gelation into microspheres in the pre-curing zone before being transported for further curing.
Other Models (N° 2, 3, and 4): These configurations require:
System Operation: The OB1 pressure controller manages fluid flow through microchannels, precisely controlling the introduction of PVA solution and the oil phase. Accurate pumping of the three solutions into the PDMS chip is monitored by flow rate sensors, with stability and reaction speed directly tied to flow rates and ratios in the microfluidic channels.
This setup offers the most precise microfluidic flow control on the market, ensuring excellent monodispersity and reproducibility of microspheres. Additionally, the process can be automated using Elveflow’s software, optimizing the production and providing real-time feedback for troubleshooting and adjustments.
Elveflow Software: Elveflow software allows easy programming of flow rates and control over droplet size and microsphere production rates. It provides real-time feedback on flow rate and pressure, helping you optimize the process and address any issues efficiently.
PVA microspheres have a wide range of applications due to their versatility and biocompatibility:
Imaging: PVA microspheres serve as contrast agents in imaging applications, providing a high signal-to-noise ratio. Their biocompatibility makes them ideal for medical and biological imaging.
Tissue Engineering: PVA microspheres offer structural support as scaffolds, promoting cell proliferation and tissue regeneration.
Gene Therapy: These microspheres can encapsulate and deliver genetic material to specific targets, making them effective in gene delivery applications.
Controlled Drug Release: With their porous structure, PVA microspheres are perfect for sustained drug release, allowing precise targeting over time.
Cosmetics: In the skincare industry, PVA microspheres are valued for their exfoliating properties and their role in delivering active ingredients.
Diagnostics: PVA microspheres can be loaded with diagnostic molecules to detect biomarkers in the body. Their high loading capacity enables the storage of DNA probes and antibodies for disease detection.
This setup enables the production of PVA microspheres with precise size and shape control, ensuring high-performance, scalable production that saves time and costs across various industries and applications. Create customized PVA microspheres tailored to your specific research needs with our all-in-one configuration.
Chip Design for PVA Microsphere Formation
Designing your microfluidic chip is essential for achieving precise control over the features of your PVA microspheres. Throughout the PVA formation process, emulsions can be formed using either a coaxial flow or a T-junction approach, with the flexibility to use two or three input solutions.
Key factors to consider in your design include the amount of input substances, the shape of the junction where substances interact to form microspheres, and the desired size and shape of the microspheres. The choice of microfluidic design also depends on the concentration and viscosity of the PVA solution and the type and number of inlets available.
Available Chip Designs:
Considerations for Input Substances:
When configuring your microfluidic system, it’s important to decide how many input substances you will use. This decision impacts the channel design of the microfluidic chip and the overall production process. The number of inlets can affect the control you have over emulsion stability, crosslinking speed, and the uniformity of the microspheres.
Geometry Choices for Microsphere Formation:
Two common geometries are used in microfluidic systems for PVA microsphere formation:
Advantages of Each Approach:
T-Junction Geometry:
Coaxial Flow Configuration:
Final Considerations:
Once you’ve determined the design features for your microfluidic system, you can integrate them into your setup to start producing customized PVA microspheres tailored to your research needs.
Our products are fully customizable to perfectly match your specific needs. Our team of specialists and researchers is here to help you select the best instruments and accessories for your application. We’ll support you throughout the setup of your microfluidic platform, ensuring you achieve the experimental results you’re aiming for.
If you have any questions about how this setup can be tailored to your requirements, please contact our experts.
– Explore our other use cases for various applications –
For any help to determine what microfluidic instruments you need, you can contact us! Our experts will help you build the best microfluidic setup for your application, with our state-of-the-art microfluidic line.
Get a quote
Name*
Email*
Message
Newsletter subscription
We will answer within 24 hours
By filling in your info you accept that we use your data.
Collaborations
Need customer support?
Serial Number of your product
Support Type AdviceHardware SupportSoftware Support
Subject*
I hereby agree that Elveflow uses my personal data Newsletter subscription
How can we help you?
Message I hereby agree that Elveflow uses my personal data Newsletter subscription