Application type: Setup: droplet and digital microfluidics

How to perform nanobubble generation? This application note will focus on the generation of bulk nanobubbles by pressure-driven flow controlled microfluidics based on the PhD Thesis entitled "Microfluidics investigation of foam stability" Leslie Labarre from the University of Birmingham. Introduction to microfluidic nanobubble generation In nature, there are two kinds of nanobubbles in aqueous solutions: … Continued

How does microfluidics alginate beads production work? Highly monodispersed alginate beads with size in the 50µm range. Experiment results by Elveflow team. Introduction to alginate beads production Hydrogel-based delivery systems are finding more and more applications, from encapsulation, protection, to the release of bioactive agents in many fields such as pharmaceutical, supplements, food industries, for … Continued

Sequential Production and Trapping of Droplets The microfluidic chip Fluidic 719 consists of a flow focusing droplet generator connected to a channel with 2261 microfluidic droplet traps of 173 μm diameter. The microfluidic traps work by floatation, profiting from the difference in density of the two phases of an emulsion. If droplets of the same … Continued

Droplets generation & manipulation Introduction Droplets generation and manipulation by microfluidics offer tremendous advantages compared to more common generation techniques such as batch methods. Droplet-based microfluidics consists in manipulating discrete volumes of fluids in an immiscible phase, such as water droplets in oil.  The main advantages are the following: Advantages Better control over small volumes … Continued

Double emulsion for encapsulation using microfluidics Introduction to double emulsion using microfluidics Double emulsions (DEs) are colloidal structures that co-localize amphipathic properties. They can be water-in-oil-in-water (W/O/W) or oil-in-water-in-oil (O/W/O) droplets. The use of immiscible liquids prevents transport across inner and outer environments, providing DEs with great protective capabilities for cargo [1].  The most common … Continued

Antifungal screening on chip Introduction to antifungal screening Pressure-driven flow controlled droplet-based microfluidics and single spore encapsulation offer the key for a breakthrough in antifungal screening and fungicide discovery.  This application note focuses on an application of droplet-based microfluidics through a platform for single-spore analysis and high-throughput antifungal screening. Fungicide discovery requires screening of a … Continued

Single cell encapsulation Single cell encapsulation background To obtain meaningful biological data from single-cell experiments, the analysis of a large number of individual cells is required. This can be achieved using pressure-driven flow-controlled droplet-based microfluidics. The microfluidic platform described in this application note is used to generate picoliter-sized microdroplets to encapsulate HeLa cells at the … Continued

How to perform microbubble generation? Introduction to microbubble generation Microbubble generation schematic1 Foams are composed of microbubbles dispersed in a liquid continuous phase. Foam properties rely on microbubble generation properties and performances. Due to the interplay between several length scales, foam properties are complex and require a fine tuning to facilitate their study. Consequently, microfluidics … Continued

How to perform microfluidic single spore encapsulation? Introduction to microfluidic single spore encapsulation Single spore of Alternaria alternata encapsulated in droplet This single spore encapsulation application note will show you how highly monodispersed droplets can be easily generated to encapsulate single spore of fungus using a microfluidic droplet generation system. For more insight into single … Continued

Dynamic control of droplet generation in microfluidic networks Generating droplets in microfluidic networks Two-phase flow microfluidics allow to perfom different laboratory functions on one microfluidic Lab-on-Chip (LoC) platform. An example of such an application is the controlled production of droplets on chip. Up until now, the sequence of elements by which droplets containing biological/ chemical … Continued