Spatial epigenome–transcriptome co-profiling of mammalian tissues 8 September 2024 By louise Spatial epigenome–transcriptome co-profiling of mammalian tissues The article titled “Spatial Epigenome–Transcriptome Co-Profiling of Mammalian Tissues” published in Nature, presents groundbreaking methodologies that integrate spatial epigenomics and transcriptomics to co-profile chromatin accessibility and gene expression in the same tissue sections. This dual-layered approach provides a more detailed understanding of gene regulation within the tissue architecture, enabling … Continued
Best Practices for Single-Cell Analysis Across Modalities 22 August 2024 By louise Best Practices for Single-Cell Analysis Across Modalities Introduction Single-cell technologies have revolutionized our understanding of cellular heterogeneity, enabling the simultaneous profiling of multiple molecular modalities. This review outlines best practices for the comprehensive analysis of single-cell data across different modalities, providing guidance on integrating and interpreting these diverse datasets. Cellular state is characterized by various … Continued