Fully automate several days of experiment
Smooth, pulseless control of flow rates and flow directions of media
Full control of fluidic parameters in one or several parallel chips
User-friendly equipment with quick setup and intuitive software
Elveflow’s Organ-On-Chip Pack setup uses a pressure controller to flow one or several medium through a microfluidic chip containing your cells of interest. Combined with flow sensors and the software, the setup allows a very accurate and stable control of the flow rate over defined periods of time.
Whether you want to add multiple fluidic channels, customize your microfluidic chip or add a vacuum control, our microfluidic specialists can customize the pack so that it can best fit your experimental needs.
Contact us for more information!
Organs-on-chips applications do not only have several advantages such as miniaturization, integration and low consumption, but also they allow researchers to accurately control the multiple parameters of a system such as chemical concentration gradient, fluid shear stress, cell patterning, tissue-tissue interface, organ-organ interaction and so on. They aim at mimicking the complex structure, microenvironment and physiological function of human organs.
These applications hold the promise of having a significant impact on improving the predictability of drug screening models and personalized medicine. Organ-on-a-chip technology supports these research areas by providing an environment that can mimic human physiology and morphology in vitro better than traditional static cell culturing methods.
The Organ-On-Chip Pack can be used with any commercial chip or self-made chip.
As an example of a commercial chip, ChipShop provide versatile chips for several applications including 3D cell culture and organ-on-a-chip. Particularly, the cross flow membrane chip (Fluidic 480) enables to create a tissue interface to mimic organs functions (gut-on-chip, brain-on-chip, kidney-on-chip, skin-on-chip, etc.).This chip hosts two different culture chambers separated by a permeable membrane. Different cell types can be seeded on one or both sides of the membrane and exposed to dynamic flow conditions.
Microfluidic chip with 2 independent chambers for organ-on-a-chip studies
There are several chip designs available for organ-on-chips experiments, depending on the type of organs that scientists would like to mimic and the experimental protocols. Elveflow is working closely with several organ-on-chips providers to supply the most suitable chip for your science.
To help you determine your flow rate, pressure to apply, the best tubing resistance length for your setup, wall shear stress for biology applications, cell culture, and many more…
Elveflow provides a dedicated microfluidic calculator to support experimental design. To make the most of this tool, find below a selection of relevant application notes.
Gut-on-a-chip and 4D imaging to understand pathogen invasion Demonstrates how dynamic perfusion and real-time imaging can be combined to study pathogen invasion mechanisms in a physiologically relevant gut-on-chip model. Read more
Human bladder-on-chip model Presents a microfluidic bladder-on-chip platform enabling controlled flow conditions to study bladder physiology and disease under dynamic culture. Read more
Microfluidic constriction assay reveals fibrotic stiffening in a spheroid model of myocardial ischemia Uses a microfluidic constriction assay to quantify mechanical stiffening in cardiac spheroids, offering insight into fibrotic progression after ischemic injury. Read more
Microfluidic perfusion for dynamic cell culture Explains how continuous and controlled perfusion improves cell viability, nutrient delivery, and physiological relevance in microfluidic cell cultures. Read more
Medium recirculation for dynamic cell culture Describes how recirculating culture medium enables long-term dynamic cell culture while reducing reagent consumption. Read more
How to stain cells cultured in a microfluidic chip Provides guidelines for performing reliable and homogeneous cell staining within microfluidic devices under flow conditions. Read more
Automated cell seeding Shows how automated flow control enables reproducible and homogeneous cell seeding in microfluidic channels. Read more
Perfusion medium switch using ibidi chips Illustrates rapid and reproducible medium switching in ibidi chips for stimulation, drug testing, or wash steps under controlled flow. Read more
Circulating tumor cells entrapment using microfluidics Demonstrates how microfluidic flow control can be used to isolate and study circulating tumor cells under physiological conditions. Read more
Recirculating perfusion microfluidic system Details a complete recirculating perfusion setup for long-term culture, combining stable flow control and reduced medium consumption. Read more
Construction, evaluation, and applications of renal barrier-on-a-chip system, Bioactive Material, Tuya Naren et al., May 2026 https://doi.org/10.1016/j.bioactmat.2025.12.032
Proximal tubule-on-chip as a model for predicting cation transport and drug transporter dynamics, Scientific Reports, Isy Petit et al., January 2024 https://doi.org/10.1038/s41598-025-85653-4
Simple design for membrane-free microphysiological systems to model the blood-tissue barriers, Organs-on-a-Chip, By Ashlyn T. Young et al., December 2023 https://doi.org/10.1016/j.ooc.2023.100032
Microfluidics-on-a-chip for designing celecoxib-based amorphous solid dispersions: when the process shapes the product, Drug Delivery and Translational Research, Joana Figueriredo et al., June 2024 https://doi.org/10.1007/s13346-024-01633-7
A microfluidic circulatory system integrated with capillary-assisted pressure sensors
Lab on Chip, Y. Chen, H. N. Chan, S. A. Michael, Y. Shen, Y. Chen, Q. Tian, L. Huang and H. Wu, 2017
Bioengineered Human Organ-on-Chip Reveals Intestinal Microenvironment and Mechanical Forces Impacting Shigella Infection
Cell Host & Microbe, Alexandre Grassart et al., 2019
A Fast Alternative to Soft Lithography for the Fabrication of Organ-on-a-Chip Elastomeric-Based Devices and Microactuators
Science Advances, Daniel A. Ferreira et al., 2021
Elveflow’s expert in liquid actuation & flow control recommend the use of relevant chips with these advantages:
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Complete your set
Microfluidic Flow Controller >>
MFS Microfluidic Flow Sensor >>
Microfluidic Bubble Trap >>
MUX Distribution Valve >>
“Elveflow provided an excellent solution to our problem, which was how to tightly control minute flows in multiple microfluidic channels.-”Dr. Robert Ward, Massey University, United StatesOB1 pressure-driven flow controller user
“We really appreciate the stability and low response time of the flow controller, which is important when various flow conditions must be applied successively. The flow can be precisely and easily controlled thanks to a user-friendly interface.”Dr. Marie Frénéa-Robin, Laboratoire AMPERE, Université Claude Bernard LYON 1, FranceOB1 pressure-driven flow controller user
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