Microfluidic news

Organ-on-chip technology for biomedical research

First stage deadline : 19th September 2023

Elvesys – the ideal SME partner for your Horizon Europe consortium!

Elvesys is a French SME specialized in microfluidic instrumentation and flow control systems for organ-/ tissue-on-chip systems and automated cell culture. We would be happy to help design your in vitro model for the replacement of animal testing in biomedical research and to share our expertise in Horizon Europe project writing and management for the call “Innovative non-animal human-based tools and strategies for biomedical research”. Feel free to contact us and discuss your project idea!

Elvesys microfluidics in vitro models for biomedical research

Organ on chip technology for biomedical research

Why should you use microfluidics for your animal model alternative?

Organ-on-chip platforms can recreate human organs or tissues remarkably well
Perfusion of your organ-on-chip device allows the injection of programmed sequences of media and drugs
We develop automated tools that will simplify the access of researchers and pharma to microfluidics technology
Microfluidics allows to pave the path towards less animal testing and more reproducible results for biomedical research

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Innovative non-animal human-based tools and strategies for biomedical research

What can microfluidics do for the development of human-based models in biomedical research?

Microfluidic medium perfusion of your cell culture will allow a control of the microphysiological conditions close to the real environment that cells grow in, in the human body. Applying controlled perfusion allows to add shear stress to the cell culture, knows to be required for cell maturation and differentiation. In addition, pharmaceutically active compounds can be added to the in-vitro cell culture in a highly precise manner, and samples can be taken continuously, and not only at end-points. If needed, the cells can be observed under a microscope and images of the cells can be taken at any moment. This way, the objectives of the call Innovative non-animal human-based tools and strategies for biomedical research can be met in an innovative manner.

Development of new in vitro drug screening models for biomedical research

⇒ There is a critical need to improve the diagnosis, drug discovery and development pipeline to increase the success rate of new therapeutics (as low as 3.4% for cancer drugs) and to provide earlier detection and treatment. Microfluidic cell-based assays and analyses are one of the most promising strategies, supported by direct feedback from industry and regulatory agencies.

Organ- and tissue-on-chip systems in disease modeling

⇒ Animal tests are more and more limited by European regulations. The cell-culture-on-chip allows to reproduce very precisely the cell microenvironment, in terms of chemicals in contact with cells, but also regarding the physical parameters (temperature, shear stress imposed on cells, etc…). They are thus much more relevant human models than conventional cells culture and are excellent candidates to replace animal testing in biomedical research.

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What we can do for the “Innovative non-animal human-based tools and strategies for biomedical research” call, as an SME partner:

For this Horizon Europe call on in vitro models development, we can bring our expertise in microfluidic instrumentation and flow management to help you develop a dynamic cell culture or an organ-on-chip platform for your project that can be automatised and user-friendly.

Specifically, Elvesys can:

Support the development of novel in vitro models
Propose a user-friendly organ-on-chip system to recreate the human microphysiological environment
Automatize the fluid handling inside your system, including media perfusion and drug administration