Elveflow’s Organ-On-Chip Pack setup uses one flow controller to flow a medium through a chip containing the organ cells. The software allows a very accurate and stable control of the flow rate over defined periods of time.
Organ-on-chip pack
Organ-on-a-chip pack
Microfluidic flow control & chip solutions for organ-on-a-chip experimentsEffortless long-term experiments
Fully automate several days of experiment
Mimic physiological conditions
Smooth, pulseless control of flow rates and flow directions of media
Reproducible and scalable
Full control of fluidic parameters in one or several parallel chips
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User-friendly equipment with quick setup and intuitive software
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Features & Benefits
Fully customizable pack
Whether you want to add multiple fluidic channels, customize your microfluidic chip or add a vacuum control, our microfluidic specialists can customize the pack so that it can best fit your experimental needs.
Organs-on-chips applications do not only have several advantages such as miniaturization, integration and low consumption, but also they allow researchers to accurately control the multiple parameters of a system such as chemical concentration gradient, fluid shear stress, cell patterning, tissue-tissue interface, organ-organ interaction and so on. They aim at mimicking the complex structure, microenvironment and physiological function of human organs.
These applications hold the promise of having a significant impact on improving the predictability of drug screening models and personalized medicine. Organ-on-a-chip technology supports these research areas by providing an environment that can mimic the human physiology and morphology in vivo better than traditional static cell culturing methods. Scalable organ-on-a-chip production is made possible by combining the technologies originating from both the semiconductor and molecular biology industries.
Organ-on-chip microfluidic devices
The Organ-On-Chip Pack can be used with any commercial chip or self-made chip.
ChipShop is a company offering versatile chips for several applications including 3D cell culture and organ-on-a-chip. Particularly, the cross flow membrane chip (Fluidic 480) enables to create a tissue interface to mimic organs functions (gut-on-chip, brain-on-chip, kidney-on-chip, skin-on-chip, etc.).This chip hosts two different culture chambers separated by a permeable membrane. Different cell types can be seeded on one or both sides of the membrane and exposed to dynamic flow conditions.
Microchip with 2 independant chambers for organ on chip studies
There are several chip designs available for organ-on-chips experiments, depending on the type of organs that scientists would like to mimic and the experimental protocols. Elveflow is working closely with several organ-on-chips providers to supply the most suitable chip for your science.
- ChipShop
- Ibidi
- BeOnChip
- Initio Cell
- Synvivo
- MesoBioTech
To help you determine your flow rate, pressure to apply, the best tubing resistance length for your setup, wall shear stress for biology applications, cell culture, and many more…
Elveflow provides its microfluidic calculator and…to make the most of our microfluidic calculator, find below a set of dedicated application notes:
Application notes
- Gut on a chip to understand pathogene invasion
- Development of a human bladder-on-chip model
- An easy guide to do microfluidic perfusion for dynamic cell culture
- Unidirectional medium recirculation for microfluidic cell culture
- How to stain cells cultured in a microfluidic chip for dynamic cell culture?
- Automate cell seeding in a microfluidic chip for dynamic cell culture
- How to perform medium switch and custom flow patterns in IBIDI© chips
- Circulating Tumor Cells entrapment using microfluidics
- How to perform fluid recirculation ?
- Tissue-engineering: Heart Ventricule assisted by a microfluidic pressure pump
Reviews
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- Organs-on-chip: Review
- Organs-on-chip: The companies
- Organs-on-chip: review from H2020 EU project
- Microfluidic mini-brains: keeping up with the brain-on-chip technology
- Liver-on-chip: keeping up with the technology
- Gut-on-chip: keeping up with the technology
- Heart-on-chip
- Recent research breakthroughs in lung-on-chip technology
Publications
A microfluidic circulatory system integrated with capillary-assisted pressure sensors
Lab on Chip, Y. Chen, H. N. Chan, S. A. Michael, Y. Shen, Y. Chen, Q. Tian, L. Huang and H. Wu, 2017
Bioengineered Human Organ-on-Chip Reveals Intestinal Microenvironment and Mechanical Forces Impacting Shigella Infection
Cell Host & Microbe, Alexandre Grassart et al., 2019
A Fast Alternative to Soft Lithography for the Fabrication of Organ-on-a-Chip Elastomeric-Based Devices and Microactuators
Science Advances, Daniel A. Ferreira et al., 2021
Content
- 1 x OB1 2 channels
- 2 x flow rate sensors
- 2 x reservoirs
- All necessary accessories: tubing, connectors, filters, etc…
- Elveflow’s flow control & automation software
Chips
Elveflow’s expert in liquid actuation & flow control recommend the use of relevant chips such as the MesoBioTech solutions with these advantages:
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- In-vivo like extracellular matrix
- Nature or synthetic biopolymers
- High porosity
- Easy handling
- Easy device integration
- Compatible with conventional culture
Options
- 1x MUX Distribution for sequential injection of medium
- Additional pumping channels for flowing several media sequentially into the chip
- Vacuum channel for inducing mechanical stretch in organ-on-chips (exp: gut-on-chip, lung-on-chip…)
- Bubble Trap for removing all bubbles from the microfluidic setup
- Pressure Sensors to measure pressure drop in the system
- Mux recirculation Valve to enable recirculation of medium (see also our Microfluidic Recirculation pack)
- Additional flow rate sensors
- Computer
- Microscope and camera
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