SET-UP TIME : 10-15 MIN / DIFFICULTY : *****
This application note shows how to perform an ultra-fast microfluidic medium switch (drugs, samples, etc) in an hypothetical chemical or biological environment, performed with an Elveflow® OB1 and an Elveflow® MUX as shown in these pictures:
We propose another configuration (using only an Elveflow OB1) to perform a fast flow switch. Click here to see the Application Note.
We also recommend to see the following review comparing the two configurations (OB1 or OB1+MUX).
These pictures show the microfluidic setup that will be used to perform a ultra-fast medium switch in this application note.
As often as possible, avoid using soft tubing (like Tygon) which involves compliance and then increases the response time of the system. If you’re not familiar with microfluidic tubings, you may read our dedicated tutorials.
The following diagram illustrates the complete chain of elements involved in this application note. You will need to assemble all these parts to set up your experiment:
Using the Elveflow® smart interface to perform an ultra-fast medium switch:
Make sure that all the cables and tubings are well connected to your Elveflow devices (USB cable, 24V DC, etc).
Perform leakage tests and remove any air bubbles before starting your experiment to ensure a good flow regulation. Knowing what fitting is best suited for your needs is a first step towards success. If you’re not familiar with microfluidic fittings, you may read our specific tutorials.
In order to monitor the pressure to perform an ultra-fast medium switch, it is necessary to follow the next steps:
These equilibrium pressure rates will ideally not be far from being the same or very similar on the three channels but it will depend on different factors, such as the different density of the mediums used, the different resistivity of the setup (the number and type of connectors, the length of tubing used, etc).
Congratulations! You can now perform an ultra-fast medium switch using an Elveflow® OB1 and an Elveflow® MUX!
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Do you want tips on how to best set up your microfluidic experiment? Do you need inspiration or a different angle to take on your specific problem? Well, we probably have an application note just for you, feel free to check them out!
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