Review Type: Organs-on-chip & 3d cell culture

ORGANOIDS VS ORGAN-ON-A-CHIP: A Comparative Review of Advanced In Vitro Models The advancement of in vitro models has reshaped the landscape of biomedical research, providing unprecedented opportunities for simulating human organ functions. Microphysiological systems (MPS), encompassing organoids and organ-on-a-chip (OoC) technologies, are redefining how we study human biology. These systems represent a significant step forward … Continued

Authors:Emilie Grandfils, Julie Cavallasca and Guilhem Velvé Casquillas With the support of the NMBP-RIA PANBioRA projectGrant agreement number: 760921 Introduction to the liver-on-chip Figure 1: Placement of the liver in the body Today’s issue The liver is involved in more than 300 vital functions [1], but is mainly known for being part of the digestive … Continued

Lab-On-a-Chip drug testing in Microfluidics Introduction Microfluidics has emerged as a powerful tool in the field of drug testing, offering unique advantages over traditional methods. This technology involves the precise manipulation of fluids at the microscale level, enabling researchers to conduct experiments with minimal sample volumes and high throughput. By leveraging the principles of microfluidics, … Continued

Exploring Organ-on-a-Chip Technology: A comprehensive review Introduction Organ-on-a-Chip (OoC) technology represents a groundbreaking advancement in biomedical research, offering a transformative approach to mimic the complex microenvironments and physiological functions of human organs in vitro. These microfluidic devices incorporate small structures designed for cell culture, creating precise biochemical and mechanical stimuli to recreate physiologically relevant conditions. By … Continued

3D Cell Culture Methods and Applications

Authors:Hadrien Mauriac, Christophe Pannetier and Guilhem Velvé Casquillas* *corresponding author: Elvesys SAS, 172 Rue de Charonne75011 Paris Introducing Organs on Chip Today, pharmaceutical companies spend more and more money for clinical trials, and put less and less new therapies on the market. Now is the time to find a solution to accelerate research. Testing on … Continued

Microfluidic "Mini-brains": Keeping up with the brain-on-chip technology The head traumas described in the Edwin Smith Papyrus among other medical states represent a proof of neuroscience interest already 1500 years before JC [1]. However, even with years of study, much remains unknown about the CNS (central nervous system)—as asserted by Pamies & al. [2]—much more … Continued

Coronavirus (SARS-CoV2) diagnostic with microfluidics Morphology of Coronavirus SARS-Cov2. Source image: Centers for Disease Control and Prevention. Coronavirus (COVID-19) information in short: The COVID-19 form of coronavirus is an infectious disease that can cause serious illness, especially in the elderly, and in those with underlying medical problems We know the virus' genetic sequence, as well … Continued

3D cell culture: market and industrial needs Review written with the support of the TrueCell H2020-MSCA Marie-Curie-Action “Individual Fellowships” Grant agreement number: 753785 Written by Alexandra Boussommier, Postdoc alexandra.boussommier@elvesys.com All living tissues are made of cells. To study cells, scientists isolate them from their original tissues and grow them in controlled and artificial environments: this … Continued

Heart-on-chip definition What is a Heart-on-chip? Heart-on-chip. Source : Kevin Parker, PhD, Harvard University A heart-on-chip is a microfluidic chip reproducing the mechanisms of a heart, in order to test medicine quickly and observe the reaction of heart cells. Great care is given to mimic the mechanics of a heart in an artificial structure, lined … Continued