The Mechanobiology pack brings together 4Dcell‘s cell confinement technology with the best in pressure control from Elveflow.
A standard setup contains a pressure controller and a cell confiner to better mimic in vivo cell culture conditions. The OB1 pressure controller from Elveflow generates stable pressure and vacuum while the cell confiner from 4D Cell provides micrometric control of the culture microenvironment.
The combination of cell compression and spatial control provides insight into cell behavior in confined spaces and under mechanical stress, increasing the translational value of in vitro cell-based assays.
Advantages for mechanobiology studies
- Control both pressure & physical space: Ideal for mechanical stress assays.
- Allows fast switches between pressure settings: For real-time observation of cell responses to mechanical stimulus.
- Stable & pulseless pressure: Total and stable control over cell compression.
- Non-destructive cell assay: Retrieve your cells for molecular analysis.
- Instantaneous start and stop pressure: Rapid trigger and release confinement.
Our dedicated pack can be adapted for more complex and advanced experiments. Contact us for more information!
Contents of the Cell confinement pack
- 1 x OB1 pressure controller
- 1 x Pressurized reservoir
- 3 x 4Dcell Confiner (PDMS suction cup)
- PDMS ring-shaped stencil – delimits the seeding area of cells to the region where confinment is applied
- 12 x Confinement slides:
- 10 mm diameter glass cover slips containing the PDMS micro-structures (pillars)
- Confinement heights from 1 to 20 µm (you may select up to 3 heights for your kit)
- 1 x Tubing and connectors kit
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