Microfluidics application note
Published on 27 August 2019
The advent of microfluidics as a tool for chemical synthesis is coming of age, particularly in industrial techniques. It has many advantages over conventional techniques such as as small reagent consumption, improved selectivity, less strigent reaction clean up, rapid reactions and small footprints.
Ensure a perfect control over your flow rate
Screen a large range of variables. Suited for production.
40ms settling: lowers the loss of expensive samples
Create your own sequence.
Applications
- Polymer synthesis
- Organic synthesis
- In-chip reagent mixing
- Manufacturing complex
- Green chemistry
- Drug discovery
- Sample preparation
- Drug screening
Flow Chemistry Set-up
A fluidic system dedicated to Flow chemistry
Elveflow® provides a unique system dedicated to Flow chemistry and sample preparation. This fully integrated solution includes all the necessary elements to create a continuous flow and monitor flow rate.
Mix between 18 different reagents
For experiments requiring mixing different components in different amounts.
Using two 13 ports / 12 positions valves it is possible to mix up to 18 different reagents (one vial for each selector valve being needed for the washing sequence). The use of the microfluidic Coriolis Flow sensor ensures a fine control for mass injection and to finely tune the ratio of the different liquid injected. Then, the use of a 3/2 valve at the outlet of the chip allow to direct the output of the mixing chip either to a waste for the washing step of the the collection vial for the compound of interest.
Reactor – Mixing chip
With regards to Microfluidic Mixers you can take a look to the following review or contact our team for advice.
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The above video showcases the stability of the controller.
We are injecting three different liquids inside a channel and perfectly tuning the ratio of the different liquids. It is particularly useful for the applications mentioned earlier.
Benefits of flow chemistry
- Small vials for expensive samples
- Large vials for long term experiment
- Disposable parts
- Washing steps (no cross contamination)
- Modular, upgradable and scalable
- 0.2% accuracy for flow injection
- Automate injection
- Small footprint
- High chemical compatibility (PEEK, Stainless steel)
Conclusion
Microfluidics has a lot of advantages over conventional techniques for flow chemistry and sample preparation. It paves the way to new applications and better control.
Microfluidics knowledge
Do you want tips on how to best set up your microfluidic experiment? Do you need inspiration or a different angle to take on your specific problem? Well, we probably have an application note just for you, feel free to check them out!
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