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[introduction_texte] => Experimental microfluidic setup for automated sampling, ensuring faster and more precise results for Continuous Analysis.
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[titre] => Optimize your process control
[texte] => Reduce costs and contamination, minimize waste and improve product quality
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[titre] => Eliminate manual and time-consuming steps
[texte] => Analyse and collect multiple data points in an automated way
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[question] => I want to analyse different samples sequentially, what system do you recommend?
[reponse] => If you want to sequentially analyze different samples, we recommend adding a second MUX Distribution valve in between the 3-way valve and the reservoirs. It is then possible to select one sample out of a maximum of 12 samples.
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[question] => How can I control the flow rate of the solution going into the analytical system?
[reponse] => Adding a flow sensor and coupling it with the pressure controller enables the fine control and tuning of the flow rate in the system. Depending on your requirements, you might choose a BFS or a MFS flow sensor.
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[question] => Is this system compatible with solutions containing suspended particles?
[reponse] => We do not recommend the use of the MUX Distribution with solutions containing suspended particles. We advise you to filter your solutions with a 10 µm filter when using a MUX Distribution valve. With the exception of the MUX Distribution valve, all the others are compatible with the solutions containing suspended particles.
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[question] => What volumes can I analyze?
[reponse] => All kinds of reservoirs are compatible with our OB1 pressure controller. From 800 µL to several liters, explore our full range of reservoirs, all compatible with the Elveflow ecosystem and choose the one that fits your needs the best. You don’t find the volume that would correspond to your needs, contact our expert for more information.
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[question] => Is it possible to control the system without using the ESI software?
[reponse] => The instruments presented in the setup are compatible with our Software Development Kit . Our package allows developers to integrate Elveflow systems into their own control programs. Those libraries enable fast and easy integration of our instruments to your lab project. We provide the following libraries free of charge (with documentation and example codes): C++ library, Python library, MATLAB library, LabVIEW library.
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[question] => Is it possible to control the system without a computer?
[reponse] => The system presented in this use case requires a computer to run. However, all the different instruments are available in their advanced version with improved automation capabilities. This Advanced range would be perfect for this specific need as the main module of the range, the Control Center , is a dedicated PLC (programmable logic controller). You can program and save microfluidic instructions on the control center and then run experiments without a PC. Everything is then controlled by the control center. The Pressure Controller , the Rotavalve Distribution and the Valve Hub will complete the collection of the Advanced modules needed for this use case. Contact our experts at Elveflow to get more information on the capabilities of this range!
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[texte] => Controlling reaction kinetics is crucial for time-sensitive processes that evolve rapidly. Whether for a deeper understanding of reaction dynamics or for automatic termination upon reaching target conditions, continuous monitoring can be the key to success.
Elveflow presents a setup tailored for sampling processes, enabling users to extract small liquid volumes from a reactor, transport them to an analyzer, and ultimately collect them in individual vials.
The setup is highly versatile and can be customized to meet specific user requirements. Users can adjust parameters such as the number and volume of collection vials, the number of samples analyzed or collected, and other aspects of the process. Our experts are available to assess feasibility and recommend the optimal configuration to achieve your goals.
Thanks to the versatility of the instruments, and the upgradability of our range , the process can evolve along with your requirements, and can thus be used for both the prototyping and the final solution.
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[texte] => We provide a full set of instruments to quickly and efficiently optimize your sampling work flow. One of the possible configurations is shown in the following setup:
Automated sampling for continuous analysis The system includes:
What you should have from your end:
Analytical system: for example a spectrometer or chromatography system The sample to analyze
For your convenience, the sample volume can be easily adjusted by choosing the appropriate length and diameter of tubing between the liquid detector and the 3-way valve.
System operation The automated sampling at a desired time happens in the following steps:
By applying negative pressure (vacuum), the liquid goes from the reactor to the liquid detector
When the liquid detector is reached by the liquid front, the valve position is switched and positive pressure is applied
Due to the effect of positive pressure, the liquid then goes toward the analyzer of your choice, and later to the collection vial (if necessary).
These steps can be repeated as many times as necessary to eventually get complete information on the evolution of the process over time.
The rotary valve of the MUX Distribution can be switched in order to collect the analyzed samples in different vials. These samples are then easily available in individual vials for further analysis.
This process can be automated thanks to the sequence generator of Elveflow’s ESI control software .
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Bioprocess Monitoring in Cell Culture Continuous monitoring of bioproducts in the pharmaceutical, biotech, and food industries is essential for optimizing bacterial or mammalian cell cultures. These cells are cultivated for the production of monoclonal antibodies, and enzymes or studied for fundamental research, disease modeling, and drug testing.
Key Parameters Monitored: pH, dissolved oxygen (DO), by-products, and metabolites. Analytical Devices: HPLC (High-Performance Liquid Chromatography), Mass Spectrometry (MS), Spectophotometry.
This continuous monitoring prevents overgrowth and toxic by-product accumulation , enables real-time optimization of culture conditions, and reduces human intervention , minimizing the risk of contamination .
Chemical Reaction Kinetics in Chemistry In pharmaceutical synthesis and material science, understanding reaction kinetics in continuous-flow reactors is essential for optimizing product yield and minimizing waste. For example, chemical catalysis reactions, cross-linking study, and chemical thermodynamics processes, which govern energy changes and equilibrium states, are reactions that benefit from continuous monitoring. Real-time analysis ensures precise control over these processes, enhancing efficiency, selectivity, and reproducibility while reducing by-product formation.
Key Parameters Monitored: Concentration of reactants/intermediates/products, viscosity, color, temperature, and pressure. Analytical Devices: UV-Vis Spectroscopy, NMR (Nuclear Magnetic Resonance): Identifies structural changes in molecules, GC-MS (Gas Chromatography-Mass Spectrometry), FTIR (Fourier Transform InfraRed Spectroscopy).
Continuous monitoring helps determine reaction completion points, enables immediate process adjustments in continuous production, and minimizes material waste by preventing the overuse of reactants.
Environmental Water Quality Monitoring Real-time water analysis ensures continuous monitoring of lakes, rivers, industrial discharge, and drinking water facilities to detect contaminants and maintain water quality .
Key Parameters Monitored: Heavy metal contamination, pH, organic compounds, and microbial load. Analytical Devices: ICP-MS (Inductively Coupled Plasma Mass Spectrometry), TOC Analyzer (Total Organic Carbon), Ion Chromatography
Ensuring compliance with environmental regulations, real-time water analysis provides early warnings for contamination events, allowing for swift corrective actions . By continuously monitoring water quality , industries can proactively manage pollutants and minimize their environmental footprint, contributing to sustainable resource management.
Drug Development and Pharmaceutical Manufacturing Continuous analysis in small-molecule drug synthesis or biologics production ensures that every batch meets stringent regulatory standards , maintaining product consistency and quality.
Key Parameters Monitored: Drug purity, API (Active Pharmaceutical Ingredient) stability, size, and impurity profiling. Analytical Devices: LC-MS (Liquid Chromatography-Mass Spectrometry), Raman Spectroscopy, DLS (Dynamic Light Scattering)
Real-time monitoring in drug synthesis and biologics production reduces batch-to-batch variability, ensuring consistent product quality . By optimizing conditions throughout the manufacturing process, it improves production efficiency and minimizes waste . Additionally, continuous data documentation enhances regulatory compliance, providing accurate records that meet industry standards and streamline quality control .
Petrochemical and Refinery Process Control In the petrochemical industry, crude oil distillation, catalytic cracking, and polymerization reactions are monitored online to ensure process efficiency, product consistency, and operational safety.
Key Parameters Monitored: Hydrocarbon composition, sulfur content, viscosity, and molecular weight distribution. Analytical Devices: Gas Chromatography (GC), FTIR (Fourier Transform Infrared Spectroscopy), Raman Spectroscopy..
Preventing production inefficiencies and equipment fouling, continuous monitoring in petrochemical processes ensures smooth operations and maximized output. It also helps industries adhere to fuel quality regulations , avoiding costly penalties through strict composition control. By enabling early detection of potential failures, real-time data analysis minimizes downtime and enhances overall refinery efficiency .
Biomedical Research and Point-of-Care Diagnostics Automated high-throughput sampling enables real-time blood or saliva analysis, allowing for the rapid detection of disease biomarkers in clinical research and point-of-care diagnostics.
Key Parameters Monitored: Glucose levels, antigen levels, inflammatory markers, and genetic material. Analytical Device: Lab-on-a-Chip, ELISA (Enzyme-Linked Immunosorbent Assay), Electrochemical Sensors
High-throughput automated sampling accelerates diagnostics for diseases like diabetes and cancer , providing faster and more reliable results. By minimizing manual handling, it reduces the risk of errors and contamination , ensuring greater accuracy in biomarker detection. Continuous monitoring of patient biomarkers also supports personalized medicine, enabling tailored treatments and early intervention for improved health outcomes.
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Credit : Yu Song et al., (2020). Wireless battery-free wearable sweat sensor powered by human motion. Sci. Adv.6,eaay9842(2020). DOI: 10.1126/sciadv.aay9842 Licence : Public Domain Dedication
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wearable testing Use Case
The wearable testing pack is dedicated to the test, characterization, and calibration with any volumes, reproducibility, and automatization. We have tried to create a multiplexing system that automates testing to calibrate any wearable where fluidics is involved.
The main objective of this pack is to create a system that is scalable and supports proper calibration through the use of a microfluidic system and biological fluids to easily calibrate your wearable. In addition, this system can be adapted to test both liquids and gas.
AN ALL-IN-ONE PACK TO EASILY TEST YOUR wearable device
Wearables are devices that usually have integrated sensors that allow them to collect and process data. For example a patch for sweat analysis. This data can be biological and related to physical activity, health, communication and other aspects of daily life. Furthermore, these devices have a wide variety of applications and can be adjusted to different sensitivity and accuracy criteria.
wHY USE MICROFLUIDICS FOR wearable TESTING?
Currently, there are methods that allow the testing of wearables. However, these require the use of many materials and long and repetitive processes that need extensive manual operations, often done by the scientist that developed the wearable. These methods are often static and do not replicate accurately the physiology of the body. Therefore, if you want to ensure high control and calibration of your tests, you can take your experiments to the next level with the advantages offered by microfluidics.
In general, microfluidics outperforms conventional wearable testing methods in the field of realism, flow control, miniaturization, multiplexing, automation and efficiency . Therefore, because microfluidics provides a powerful and versatile platform for wearable testing, it will provide researchers and manufacturers with valuable insights into device performance, reliability, and functionality under conditions that closely mimic real-world usage scenarios.
Pros and cons of wearable testing KEY ADVANTAGES:
Microfluidic systems can replicate physiological conditions for more accurate testing of wearables .
Microfluidic devices enable precise control of fluid to ensure a appropriate wearable performance .
Microfluidic systems allow proper integration with other analytical technologies.
Microfluidics enables increased efficiency and throughput through parallel processing (multiplexing ) of multiple samples or tests in wearable assays.
Microfluidic platforms can provide precise control of sample volumes , improve mixing and reaction kinetics, and enable sensitive detection methods , resulting in more robust and accurate testing of wearable devices.
Overview of the wearable setup
How to choose the better configuration of the pack?
Here is an example of what your system could look like but there are multiple possibilities depending on if your medical device uses a single inlet or multiple and the type of tests that you need to perform.
SETUP AND CONTENT:
This wearable testing pack is based on calibration by injecting different types of samples using a sequential injection system. For more detailed information, please contact our experts .
MODEL of the setup:
We take care of the fluidic design, you take care of your science. We provide all the instruments to automate your fluidic setup. One of the possible configurations is a sequence of different analytes as shown in the following setup:
Setup 1 Wearable testing With our beta package you can test different substances in your wearable. However, if you then wish to vary the concentration, you can consult our other beta pack for concentration calibration.
Most packs use the following instruments:
Hardware:
Contact our experts to answer any questions about this wearable testing use case and how it can match your specifications!
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Calibration curve:
You can use this pack for adjusting the concentration ratio of analytes or switch from different samples, this will allow you to perform a steps or continuum analysis.
Calibration test wearable testing
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CUSTOMIZE YOUR PACK
Elveflow’s products and packs are fully customizable so they will be perfectly adapted to your needs. Our specialists and researchers can help you choose the best instruments and accessories. In addition, they will accompany you during the setup of the microfluidic platform until you can get the experimental results you need.
Elveflow can provide you with a wide range of different flow sensors, bubble detectors and traps or any relevant microfluidic instrument for the applications you need.
Please contact our experts for any questions about this pack and how it can fit your specifications.
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Application packs 2 pages found
Experimental setup for Automated Sampling Solution for Continuous Analysis with microfluidic solutions for faster, more precise results.
More
Automated system for precise wearable testing
More
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[texte] => Create your paper-based microfluidic chips
Fast protocols
Easy to handle
Double tool holder and tunable cutting parameters for more versatility
Benefits
Easy to use
Fast fabrication processes: adapted for prototyping
30×30 cm² mattress for large designs or making several designs at once
Adapted to cut over a wide range of materials
Web software and mobile application for more flexibility
Double-head tool to cut and write
Resolution down to 200µm
Included
Equipment
Cutting plotter
Rolling mill machine
Possibility of adding a PDMS station for molds creation
Accessories & Chemicals
Different paper substrates and pencils with hydrophobic ink or adhesives according to your application as well as all necessary lab accessories (tweezers, scissors, etc.) are included.
We give you all the consumable references and provider information to refill your stock.
Support
Standard support pack: We take care of the after-sale of all your instruments and provide microfabrication process-sheet and tutorials plus provide you 1-years assistance to answer any microfabrication questions you may have.
Extended support pack: In addition to the standard support pack, our R&D team installs the equipment directly in your lab. This way, we adapt all our microfabrication processes on-site fitted to your needs. We also train your team, so they are ready to fabricate microfluidic chips straight away.
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Cutting plotter :
Cutting machine with tunable pressure and number of cycles adapted to cut a wide range of materials. The blade and mattress can be adjusted according to the thickness of the material.
Cutting speed: 5cm/s
Resolution down to 200µm
Rolling mill
Rolling mill machine working with 6 rolls with 4 heating. The speed and the temperature can be adapted according to the application and can be used for thicknesses up to 3mm. The rolls can move towards and backwards and are easily cleanable.
Easy to use
Wide range of speed (up to 1,3m/min) and temperature (up to 140°C)
Digital panel for perfect parameters control
Easy to clean
Each pack can be adapted to your laboratory and technological requirements.
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Benefits
Easily and quickly create your own PDMS membranes.
Precise control over your PDMS membrane thickness.
Robust processes to enable easy reproducibility.
Fabricate your membrane without initial knowledge of microfabrication.
Get the best equipment to ensure your facility for long lifetime.
Included
Equipment:
Highly versatile Spin Coater
Air compressor
Vacuum pump
Hot plate for photoresist and PDMS baking
Accessories:
All lab accessories (glass slides, Petri dishes, disposable cups, stirring rods, scalpels, etc.) are included. We give you all the products’ references and providers’ information to refill your stock.
Chemicals:
All chemicals (PDMS, TMCS, AZ4562, Isopropanol, Acetone, etc.) are included. We give you all the products’ references and providers’ information to refill your stock.
Support
Standard support pack: We take care of the after sale of all your instruments, we provide you microfabrication process-sheet and tutorials, and we provide you 1-year phone assistance to answer any microfabrication questions you could have.Extended support pack: In addition to the standard pack our R&D team installs the Softlithobox directly in your lab, we adapt on site all our microfabrication processes to your needs, and we train your team until they become ready to fabricate all your microfluidic chips.
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Spin coater
We offer you all the equipment, accessories, and chemicals needed to make highly reproducible PDMS membranes. Prepare your PDMS, choose the thickness, and quickly create your PDMS membranes for your experiment in less than one hour!
Our system ensures you:
highly reproducible PDMS membranes Easy manufacturing of PDMS membranes High-precision PDMS membrane thickness
Wide range of PDMS membrane thickness
Vacuum pump / Air compressor
The Spin coater needs a 4bar pressure and vacuum access to work correctly. The vacuum is used to maintain the wafer on the chuck, and the pressure protects the Spin coater from the liquid, photoresist, or PDMS from getting inside the rotor.
We also provide an efficient, powerful, and noiseless vacuum pump and air compressor in case your laboratories do not have pressurized air or vacuum lines, or if you wish to install your station anywhere in your facilities.
Hot plate
Our hot plate is ideal for the final steps of hardening the PDMS or – depending on the process – baking some photoresist.
We offer a simple and efficient hot plate with the best quality and price conditions.
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An adaptive offer!
Since each laboratory is different, since each research is unique, we do adapt the offer to be as close as possible of the real need. We discuss together what will be the best efficient facility and thus add or remove equipment, accessories, chemicals.
Do not hesitate to ask one of our technico-commercials to make an assessment of your facility and to advise you on your project.
Options
We have created basic offer with every thing needed to have a complete working set, but some option can be add according to each situation. We have selected some option commonly use during softlithography process but do not hesitate to ask our engineer if you have special expectations.
Developer Agitator
Optical profiler
Little fume hood – Extractor3.5
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Benefits:
Fast fabrication process to develop your chip in 5 hours or less.Fabricate your high-resolution devices without initial knowledge of microfabrication. Highly reproducible processes from reusable molds to PMMA chip fabrication.Get advantage of our expertise in photolithography and the hot embossing process . Inexpensive and innovative process suitable for different applications.
PMMA devices present properties that convey multiple advantages such as:
Characteristics
PMMA
PDMS
Transparency Transparent and optically clear Transparent and optically clear
Fabrication Machining, laser cutting Soft lithography
Bonding Solvent bonding, thermal bonding, or adhesive bonding Oxygen plasma treatment or adhesive bonding
Elasticity Rigid Flexible and elastomeric
UV radiation resistivity Moderate to high Low
Surface properties Hydrophobic, requires surface modification for hydrophilicity
Hydrophobic, naturally hydrophilic, can be surface modified
Gas permeability Low
High
Chemical compatibility Chemically resistant to many solvents and reagents
Limited chemical compatibility, can swell or leach components
Biocompatibility Biocompatible with certain cell types and assays
Biocompatible with a wide range of biological samples
Connection options External connectors (stainless, steel, plastic)
Tubing or syringe needles
Connector compatibility & ease of connection Compatible with a variety of connector types: Requires proper alignment and connection of external connectors
Compatible with tubing or syringe needles: Tubing or needles can be easily inserted into the PDMS channels
Overall, if you want to do easy prototyping and work at low pressure, PDMS devices are a good fit for your requirements.
If you want to apply high pressure or potentially scale up your process later, PMMA must be the perfect material for you.
Depending on your final application, our experts help you define the best material to reach your goal.
This pack guarantees a total and autonomous PMMA device manufacturing for microfluidics, Bio-MEMS, or other applications.
Included Master mold fabrication (same as PDMS):
Laminator UV lamp Heat plate
PMMA replication:
Ultrasonic bath Heat press Oven Pressurized air installation Plasma cleaner
Materials:
All resources (PMMA film, dry photoresist film) are included. We also provide all product references needed to refill your stock in the future.
Accessories:
All lab accessories (glass slides, iron slides, slide holders, Petri dishes, tweezers, solvent bottles, thermal gloves, etc.) can be included. We also provide all product references needed to refill your stock in the future. The mask used depends on the application, therefore a mask design can be discussed.
Chemicals:
All chemicals (Isopropanol, acetone, developer, etc) can be included. We also provide all product references needed to refill your stock in the future.
We can also provide you:
Ultrasonic bath Drilling machine Classical designs of photomasks
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CONTENT : Laminator : An easy-to-use hot and cold laminator
Dimensions : 500*200*100mm. Laminating Speed: 560mm/min MAX Laminating thickness: 1mm
UV lamp: A functional exposure-masking chamber operating with a cold UV source with pattern resolutions down to 1µm.
Dimensions : 260*260*260mm. Wavelength: 365nm +/- 5 nm MAX Substrate thickness: 2 mm
Heat plate: A programmable hot plate with a smooth temperature ramp.
Dimensions:203*203 mm. Max temperature: 450℃. Temperature accuracy: 1%.
Heat press With Double Heating Plate:
Dimensions:420*550*680mm. Max temperature: 300℃. Pressure range: 0-25 tons.
Oven: A conventional laboratory oven
Dimensions: 150 L Max temperature: 250°C
OPTIONS :
Ultrasonic bath Drilling machine
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APPLICATIONS Thanks to its properties (transparency, recyclability, high biocompatibility), the PMMA device can be used for multiple applications such as:
Biomedical research and diagnostics: Thanks to its transparency that facilitates imagining, PMMA devices can be used for cell culturing, drug screening, DNA analysis, protein assays, and point-of-care diagnostics. Droplet-based Microfluidics: PMMA devices can be used to generate and manipulate droplets in areas like: high-throughput screening, single-cell analysis, and chemical synthesis. PMMA’s compatibility with various fluids and its hydrophobic nature allows for precise droplet generation and control. Organ-on-a-Chip: PMMA’s transparency facilitates real-time observation and analysis of organ-on-a-chip models. Environmental Monitoring: such as water quality analysis and pollutant detection. PMMA devices can integrate sensors and detection methods to analyze samples and provide rapid and portable testing solutions. Microreactors: PMMA devices can be used as microreactors for chemical reactions at the microscale. These microreactors enable precise control of reaction conditions, enhanced mixing, and reduced reaction times. PMMA’s chemical resistance and ease of fabrication make it suitable for creating microreactor systems.
Overall, PMMA is a well-known material for mass production and therefore very easy to manufacture on a large scale. Thus, if you want to go through a prototyping phase for all these applications before possibly considering larger production, it must be a suitable material for your requirements!
Our team of experts can assist you in determining the most appropriate material based on your final application, ensuring that you achieve your desired outcome.
CUSTOMIZE YOUR BETA PACK
Elveflow offers compatible instruments for standard commercialized chips from various brands. You can customize your Elveflow Beta Pack to suit your specific needs, with guidance from our specialists who will suggest the best instruments and accessories. We can also help you set up the perfusion system.
Elveflow provides a broad range of reservoirs, flow sensors, bubble detectors, traps, and other relevant instruments. All instruments are controlled by the same Elveflow software interface, enabling workflow automation and easy integration into your program using free available libraries.
– Check our other Beta Packs for various applications –
The BioPros and Micro4Nano projects results helped develop this instrument pack, with funding from the European Union’s Horizon research and innovation program under HORIZON-CL4-2021-DIGITAL-
Special thanks to Micaela Fernandes and Widad Mesbahi, who largely contributed to the development of this pack.
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CUSTOMIZE YOUR BETA PACK
Elveflow offers compatible instruments for standard commercialized chips from various brands. You can customize your Elveflow Beta Pack to suit your specific needs, with guidance from our specialists who will suggest the best instruments and accessories. We can also help you set up the perfusion system.
Elveflow provides a broad range of reservoirs, flow sensors, bubble detectors, traps, and other relevant instruments. All instruments are controlled by the same Elveflow software interface, enabling workflow automation and easy integration into your program using free available libraries.
The BioPros and Micro4Nano projects results helped develop this instrument pack, with funding from the European Union’s Horizon research and innovation program under HORIZON-CL4-2021-DIGITAL-
Special thanks to Micaela Fernandes and Widad Mesbahi, who largely contributed to the development of this pack.
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Benefits
Reach the same pattern resolution as in a clean room.
Get strong photoresist patterns for numerous future PDMS moldings.
Work with robust processes for easy reproducibility.
Fabricate your molds without initial knowledge of microfabrication.
Get the best equipment to ensure your microfabrication for a long lifetime.
Included
Equipment:
UV Lamp with UV LED
Highly versatile Spin Coater
Programmable Hot plate
Accessories:
All lab accessories (Silicon wafers, tweezers, pipette, tips, timer, etc.) are included. We give you all the products’ references and providers’ information to refill your stock.
Chemicals:
All chemicals (SU8, Adherence promoter, SU8 developer, Isopropanol, Acetone, etc.) are included. We give you all the products’ references and providers’ information to refill your stock.
Support
Standard support pack: We take care of the after-sales of all your instruments. We provide you with a microfabrication process sheet and tutorials and one-year phone assistance to answer any microfabrication questions you might have.Extended support pack: In addition to the standard pack, our R&D team will also install the Softlithobox directly in your lab. This way, we can better adapt all our microfabrication processes on site, fitted to your needs. We also train your team so they become ready to fabricate your microfluidic chips straight away.
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Spin-coater
This spin coater is both compact and equipped with advanced features such as a centering tool and a removable PTFE liner for easy cleaning. It accommodates wafers up to 6 inches in diameter (150mm) and square substrates measuring 5 inches x 5 inches (127mm x 127mm).The device is finely calibrated to allow for controlled and repeatable applications of photoresists or PDMS layers. Additionally, the lid features a hole to facilitate dynamic coating.
Its compact size, coupled with the attached control panel, enhances its portability. Furthermore, a built-in safety device prevents solvents from entering the engine, ensuring its longevity.
Major strengths:
Specifically designed for ease of use.
Simple programming options from the operator panel or via your PC.
Capability to set complex sequences with multiple accelerations and speeds.
Easy to clean.
Features a non-clogging system to extend its lifetime.
Low vibration operation.
Capable of speeds up to 12,000 rpm.
Available with a wafer-centering tool.
UV Lamp
This UV Lamp is a robust and compact tabletop system, accommodating samples up to 4 inches in diameter, with a 6-inch option also available. It features automated chuck movement, offering variable mask-to-substrate distance control and enabling both hard (physical) and soft (proximity) masking contacts. A specialized optic provides highly collimated light, suitable for low-resolution (2µm) printing and thick layer printing (several hundred micrometers). These features make this device particularly well-suited for microfluidic applications. Its compact size allows for flexible installation in various locations, including outside of a clean room.
Major strengths:
Provides perfectly monochromatic exposure across the wafer surface area (bandwidth lower than 10 nm).
Cold UV exposure feature.
The light’s divergence angle is less than 2°.
High power density with no warm-up time required.
Long LED lifetime: over 10,000 hours, equivalent to 8 – 10 years of use.
Fast LED switch on/off capability for photoresist flashing.
User-friendly touchscreen interface for programming exposure cycles.
Intuitive control of UV source intensity.
Automated wafer loading and unloading system.
Compatible with glass and plastic photomasks.
Directional UV beam and integrated UV meter.
No variation in UV power over time.
High UV uniformity on 4-inch wafers.
Ensure accurate, homogeneous, and stable temperature set points with this digital hotplate.
It allows for the establishment of a temperature ramp, facilitating the transition from one temperature to another before maintaining a stable temperature for a specified period.
Additionally, its thick aluminum top plate promotes slow cooling, which is ideal for various photoresist applications. Simplify your workflow by automating soft bakes and post-exposure bakes, thereby optimizing the photolithography process.
Major strengths:
Temperature ramp for heating up and cooling down.
High-temperature uniformity across a 4-inch wafer.
No drift in temperature sensors over time.
Microprocessor display ensures consistent temperature maintenance.
Minimal temperature overshoot.
Automatic timer functionality.
Smooth aluminum plate for easy photoresist cleaning.
Control time count, temperature, and set points directly from your PC.
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An adaptive offer!
Since each laboratory is different, since each research is unique, we do adapt the offer to be as close as possible of the real need. We discuss together what will be the best efficient facility and thus add or remove equipment, accessories, chemicals.
Do not hesitate to ask one of our technico-commercials to make an assessment of your facility and to advice you on your project.
Options
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An acquisition interface for all your sensors inside your setup
The Sensor Reader is an interface allowing the acquisition of many kinds of analog and digital sensors, including Elveflow’s pressure sensors and flow sensors. The Sensor Reader can be used to monitor flow rate, pressure, or other physical parameters on any type of flow control instrument (syringe pump, peristaltic pump, perfusion, pressure controller).
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MONITOR THE MEASUREMENT OF ALL YOUR MICROFLUIDIC SENSORS Connect pressure and flow sensors wherever you want in the setup to closely monitor your microfluidic experiment.OB1 flow controller should you need high control over your experimental parameters.
Benefit in an optimal manner from the performance of Elveflow® Sensors with the Sensor Reader acquisition interface. The open interface Sensor Reader also allows you to use third-party sensors.
Fast and precise
With an acquisition sampling rate of up to 200 Hz and an 16 bit resolution, the Sensor Reader allows you to easily conduct experiments involving monitoring or controlling a physical parameter with analog and digital sensors in real time.
Wide sensors compatibility
See Elveflow® fully compatible pressure sensor & flow sensor below
Noise reduction
An embedded analog 60 Hz low pass filter function can be activated on each channel independently to reduce sensor noise.
PERFORMANCE Our Sensor Reader achieves an 16 bits resolution at up to 200 Hz sampling rate and a sub-resolution noise, for accuracy levels on your sensor measurements down to 0.05% of the full scale and a response time down to 5 ms.
Sampling rate up to 200 HzResolution : from 9 to 16 bitsInput range : 0 – 10 VFully compatible with other Elveflow instrumentsMeasurement noise below resolutionNoise reduction function with a 3rd order 60 Hz low-pass filter
ELVEFLOW® PRESSURE & FLOW SENSORS – FULLY COMPATIBLEWe have already selected a wide range of integrated sensors fitting microfluidic applications.
Flow Sensors (MFS )
Resolution 1,5 pL/secRanges from 0.07 to 5000 μL/min
Pressure Sensor (MPS & MFP )
Accuracy down to 0.2 % of Full Scale4 ranges from 5 psi (340 mBar) to 100 psi (7 bar)
All our sensors are provided with an M8 electrical connection and can be used with the Sensor Reader. We also provide all the microfluidic connector kits necessary to start your experiment.
Pressure sensor feedback loop
How to study bacteria by microfluidics
Controlled microfluidic sample injection
Preparation of PLGA nanoparticles by flow focusing
All our application notes: here !
Mechanical cell compression
Performance of polymeric skin adhesives during perspiration
All our research summaries: here !
Microfluidic for cell biology: Concepts and methodologies
Thermoelectric sensor
Microfluidics for point-of-care diagnostic devices
All our reviews: here !
Publications
For all the publications using our products, please click here .
For all the application notes and reviews based on our product, please click here .
The following table summarizes the main features of the Elveflow® MSR Microfluidic Sensor Reader.
SENSOR READER UNIT SPECIFICATIONS
Number of sensors connections up to 4
Sensor connectors M8 female (4 pins)
USB reading current min – max 200 mA – 800 mA
Sensor power supplies voltage 5 – 24 V
Max total power per channel
0.9 W
SENSOR INPUTS
Impedance 1 MΩ
Acquisition frequency 200 Hz
Acquisition resolution from 9 to 16 bits
Input range 0- 10 V
Resolution (1 bit) 5 mV
Noise (full band) 5 mV rms
Compatible sensors Elveflow MFS flow sensor, MPS pressure sensor, MFP FlowPlus pressure sensor, MBD bubble detector, other sensors
Non-contractual information, may be changed without notice
SENSOR READER SIZE: without connectors (length x width x height): 91 x 69 x 29 mm WEIGHT: 320 g
Software ESI is Elveflow’s more advanced software interface, built to make experimenter’s life better. It is perfectly adapted, from simple setups control to very advanced setups and workflows automation. It embarks several modules that make time-consuming and painful tasks so simple. It comes with SDK libraries to control the Elveflow system with your own code (C++, Python, MATLAB®, LabVIEW®)
Sensor compatibility with MSR versions
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[text] => 1. ELVEFLOW’S SINGLE SOFTWARE (ESI )
Monitor and automate your setup using our ESI software that allows you to measure, control and automate your experiment using only one interface.
2. FLOW SENSOR (MFS ) OR PRESSURE SENSOR (MPS )
Place the sensors anywhere you want on your fluidic path and electrically connect your sensors to the Microfluidic Sensor Reader.
Thanks to their small footprint, sensors can be placed anywhere within your fluidic system.
3. MICROFLUIDIC SENSOR READER (MSR )
Connect the sensor reader to your computer via USB and monitor it using the Elveflow® Smart Interface
4. CHIP / CAPILLARY
Add you chip to complete the standard setup. In this position, the sensor directly measures the pressure entering the microfluidic chip. You can add another pressure sensor at the chip outlet in order to get the difference in pressure and/or the microfluidic resistance.
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Microfluidic sensor reader - MSR
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[part_1] => OB1 MK4
[part_2] => Microfluidic Flow Controller
[part_3] => 1 to 4 channels pressure vacuum microfluidic flow controller
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[titre] => PRESSURE AND VACUUM CONTROL
[texte] => Accurately control pressure to push and pull liquid
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[titre] => FLOW CONTROL
[texte] => Pair it with a flow sensor for accurate flow control
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[texte] => Down to 0.005% of the full scale range of pressure
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[introduction_texte] =>
The OB1 allows you to control the output pressure of up to 4 channels independently, from -900 mbar to 8 bar, for a wide variety of advanced microfluidic applications.
Thanks to our proprietary Piezoelectronic Technology, the OB1 MK3+ is 10 times more stable and up to 10 times faster than other microfluidic flow controllers.
What is a microfluidic pressure-driven flow controller?
Cutting-edge Microfluidic Flow Controller
Designed by scientists for scientists, the versatile and powerful OB1 MK4 pressure controller provides the perfect flow control for all kinds of applications.
The best performance on the market: Piezoelectric Technology The Elveflow OB1 MK4 is one of the best performing microfluidic flow control instruments worldwide that uses piezoelectric regulators. The piezoelectric technology gives you 20 times more precise and 10 times faster flow control than any other flow controller on the market.
Customizable & upgradable: 1 module, up to 4 channels, 5 pressure & vacuum ranges available The OB1 MK4 can be configured according to your needs. In one piece of equipment, you can have up to 4 pressure and/or vacuum channels (and other customized options).
Get the fastest flow rate control when paired with a flow sensor Connect the OB1 MK4 to a standard liquid flow rate sensor MFS )our premium Coriolis flow sensor BFS , suitable for both liquid and gas)
Full control software, SDK, and UART communication Single and intuitive software to get started in a few clicks and automate complex and long experiments.
OEM version available The OB1 MK4 can be used on a bench setup or embedded in your own product.OB1 MK4 OEM solution.
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[texte] => Applications of Pressure-Driven Flow Control
Thanks to its ultra-fast response time, high stability, and precise flow control, the OB1 pressure controller is a preferred choice for a wide range of liquid handling microfluidic applications, compared to syringe pumps or peristaltic pumps. Combined with precision flow sensors (like MFS or BFS ), the OB1 pressure controller can accurately control flow rate in any microfluidic setups. Below is an overview of how pressure-driven flow control improves research across different domains.
Droplet & Bead Generation
Droplet Microfluidics Flow control microfluidics offers unmatched stability and responsiveness when generating monodisperse droplets in microchannels. The precise flow control is essential for the generation of identical droplets avoiding most post-synthesis steps. This monodispersity is essential in applications like digital PCR, single-cell analysis, or encapsulation. Explore droplet generation setup
Alginate Bead Generation In biomedical research, alginate beads are used to encapsulate cells or molecules. Pressure-driven systems allow fine-tuned control over flow rates, ensuring uniform bead size and reliable encapsulation efficiency. See the alginate bead pack.
Biology & Cell Culture
Cell Perfusion Pressure-based perfusion ensures bubble-free, pulsation-free delivery of nutrients or drugs to cultured cells over extended periods, ideal for mimicking physiological flow conditions. Discover perfusion setup
Organ-on-a-Chip Simulating organ-level responses on chips requires controlled fluid environments. Pressure-driven systems provide the accuracy and reactivity needed to replicate dynamic flow patterns and shear stress. Learn about Organ-on-a-Chip systems
Cell Confinement Assays Experiments that study how cells adapt to physical constraints benefit from stable pressure control to reproducibly apply mechanical stress. See confinement assay example
Cell Constriction Assays Revealing cellular responses to fibrotic environments or disease models requires reproducible deformation of cells, enabled by finely tuned pressure-controlled flows. View ischemia model example
Cell Trapping & Synthetic Compartments Pressure-driven flows help trap and localize cells or materials in adapted microfluidic chips, useful in synthetic biology or compartmentalization studies. Read the synthetic cells study
Flow Control & Mixin
Sequential Injection & Mixing Delivering fluids in a precise sequence or generating on-chip gradients requires fast and programmable flow transitions. Pressure controllers enable seamless transitions between multiple fluid inlets. Explore the injection pack
Recirculation Some in vitro assays require long term dynamic flow of reagents or cell culture media. In most cases it is essential to reuse the media, in order to mimic physiological conditions or avoid expenses. Using pressure-based flow control, one-way recirculation is possible to program for long term experiments. Learn about the recirculation setup
Analytical Chemistry & Imaging
Flow Chemistry Pressure-driven systems provide accurate reagent dosing and fast startup/shutdown, essential for reaction optimization in continuous-flow chemistry. This is particularly useful in the development of immunoassays and biosensors. See flow chemistry application
Liquid-Phase Electron Microscopy (LPEM) Stable, pulseless flow is critical for imaging samples in real time at the nanoscale. Pressure control allows precise delivery of fluids during live-cell imaging under an electron beam, especially to study samples in their natural environment. Explore LPEM research
Light-Field Flow Cytometry (LFC) In high-throughput single-cell analysis, stable and controlled flow conditions are key to accurate imaging and data capture. Pressure-based systems enable high-speed and consistent sample handling. Learn about 3D LFC
Industrial Applications
Enhanced Oil Recovery (EOR) Microfluidic chips simulating porous media allow researchers to visualize oil displacement mechanisms. Pressure control enables fine adjustment of flow to mimic subsurface conditions with high reproducibility. Read the full EOR review
Cosmetic Formulation & Testing
Microfluidics offers new possibilities for precision formulation of cosmetic emulsions and nano-encapsulation of active ingredients. Pressure-driven flow ensures reproducibility and scalability for testing stability, texture, or skin permeability on-chip. Explore cosmetic applications
Integrated Systems
Lab-on-a-Chip Platforms At the core of any lab-on-a-chip system is the need for precise, responsive, and stable flow control, features inherently supported by pressure-driven microfluidics. Whether it’s diagnostics, environmental sensing, or point-of-care testing, the OB1 system provides the control backbone required for success. Discover some lab-on-chip examples in this review
Videos
Publications
For all publications featuring our products, please click here .
For all application notes based on our product, please click here .
For reviews of our product, please click here .
Channel pressure range
0 to 200 mbar(1) 0 to 2,000 mbar(1) 0 to 8,000 mbar(1) -900 to 1,000 mbar(1) -900 to 6,000 mbar(1)
Pressure stability(2)
0.015 % FS(1) 0.005 % FS(1) 0.006 % FS(1) -900 to 500 mbar
-900 to 2,000 mbar
0.005 % FS(1) 0.005 % FS(1)
500 to 1,000 mbar
2,000 to 6,000 mbar
0.007 % FS(1) 0.007 % FS(1)
Response time(3)
Down to 10 ms
Setting time(4)
Down to 50 ms
Minimum pressure increment
0.006 % FS(1) 0.006 % FS(1) 0.006 % FS(1) 0.0064 % FS(1) 0.0064 % FS(1)
Pressure supply
1.5 bar (or Max pressure + 0.5 bar) to 10 bar
Input vacuum(5)
/
Any value from -0.7 to -1 bar
Input pneumatic connector
6 mm push-in
Output pneumatic connector
4 mm push-in
Liquid compatibility
Non contact pump
Flow sensor compatibility
Compatible with the whole MFS and BFS range Monitoring and feedback loop flow control available
Flow sensor compatibility
From 0,1 µL/min to 500 mL/min (indicative, please refer to the MFS and BFS series)
Flow sensor compatibility
Non-contact pump Any aqueous, oil, or biological sample solution.
Software control
Elveflow Smart Interface – Windows 10, 11, both 32 and 64 bit versions supported
Software Development Kit
Libraries available: Matlab, Python, LabView, C++
Flow sensor compatibility
Non-contact pump Any aqueous, oil, or biological sample solution. – Windows 10, 11, both 32 & 64 bit versions supported Serial/UART communication protocol on request
Data management
Possibility to log and extract data (CSV), channel and sensor detailed information using ESI
Input profiles
Possibility to load profiles: ramp, sine, triangle, square, or custom
Automation
Generate step-by-step sequences using the ESI built-in sequence management Log and export custom configurations (CSV)
Screen
LCD screen showing pressure and sensor flow rate in real time
Voltage
24V
Typical power
12W
Power connection
DC power connector, Plug, 3A, 2.1mm, 12mm
Interface
USB Type B
Communication type
Serial
Sensor connection
M8 4-pins, one connector per channel
Compatibilit
Elveflow sensors: MFS, BFS, MPS, MFP, MBD Custom sensors: 5 to 24V supply voltage, 0 to 10V readout voltage
Triggers
Input and Output TTL signal 0V or 5V
Supply Voltage Range (V)
100 to 240 VAC
Supply AC Frequency (Hz)
50 to 60 Hz
Maximum Output Current (A)
1.67 A
Maximum Output Power (W)
40 W
Dimensions (length x width x height)
240 x 223 x 83 mm
Weight
1.4 kg to 2.9 kg
(1) Max pressure value might vary by +/- 2.5% (2) Pressure stability (standard deviation) measured over the full pressure range with an external high accuracy pressure sensor (Druck DPI150) (3) Time required to reach 5% of the setting point. Depending on your computer’s operating system (4) Time required to reach 95% of the set point. Volume dependent – Measurement was done on 12 mL reservoir for a set point from 0 to 200 mbar (5) A vacuum source is mandatory for calibration and use of dual channels even if the channels are to be used in pressure only.
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[question] => What pressure range should I choose?
[reponse] =>
The performances of the OB1 (for example, the pressure stability) is tied to the full operating pressure range.
In order to achieve optimum performance, we recommend our users to choose the smallest pressure range that covers the required experimental pressures.
)
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(
[question] => Can I achieve direct flow control?
[reponse] =>
By coupling a MFS or BFS flow sensor to the OB1 flow controller, you can use the software to directly control the flow rate by directly inputting the flow rate value.
The software uses a PID loop to control the flow rate by setting automatically the pressure to reach the requested flow rate. Doing so, you can benefit of the best of the two worlds to get a fast and precise (pressure driven) volume flow rate (flow sensor).
)
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[question] => Can I connect a Pressure Sensor to the OB1? -
[reponse] =>
Pressure and flow sensors can be connected directly to the OB1 MK4. The sensors can be used in passive mode (for monitoring only) or active mode (to enslave).
)
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[question] => Do I need a pressure and/or vacuum source to operate the OB1 Pressure controller ?
[reponse] =>
Yes, you will need a pressure source to work with the OB1 pressure controller.
You can either use the air supply of your lab if there is one, use a compressed air bottle or use an air compressor. Elveflow has selected a compressor that is perfectly fitted for most application using the OB1.
If your OB1 has a vacuum channel, you will need a vacuum pump. Elveflow also proposes a selected pump that work perfectly with the OB1.
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[question] => How to install the OB1?
[reponse] =>
Click here
Unboxing video
)
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[more_title] => Software
[texte] =>
Software ESI is Elveflow’s dedicated software interface, built to make life easier for experimenters. It is perfectly adapted for the control of simple and complex setups and workflow automation. It integrates several modules that make time-consuming and painful tasks simple. It comes with SDK libraries to control the Elveflow system from your own code.
The OB1 control window allows to:
Visualize the key parameters of each channel:
the command pressure
the output pressure
Visualize sensor output when one is connected to the OB1 (a flow rate sensor on the first channel in the video presented below)
Set any pressure or flow rate pattern (predefined or custom)
Easily switch to the flow rate control mode (sensor mode)
Use the pause/play button to preset the parameters on each channel and launch them simultaneously
Save configurations to gain time in the future or automate your workflow thanks to the sequencer
Open a graph to visualize and save data
Launch and use dedicated modules to simplify specific experimental tasks
Which sensor is compatible with OB1 MK4?
[image] =>
[video] =>
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[text] =>
Advantages of Pressure control in microfluidics
Fast settling time
High stability and pulseless flow
Possibility to handle fluid volumes of several liters
Enable both flow and pressure control when used with a flow meter
For more details about Pressure driven flow control, please read this application note .
[image] =>
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[title] => Get the perfect instrument
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[title] => ELVEFLOW PRESSURE CONTROLLER OUTLETS@2x 768x441
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[texte_1] =>
Directly connect a flow sensor Control the flow inside your microfluidic setup
[texte_2] =>
5 pressure ranges for each channel Choose the pressure range best suited to your need
We have several pressure channel options available covering a wide range, up to 8000 mbar (116 PSI) and down to -900 mbar (-13 PSI). Choose the pressure channel that covers your experimental pressure requirements.
[texte_3] =>
Choose between 1 to 4 channels, and more… How many channels do you want?
The OB1 MK4 is a compact module that can accommodate up to 4 channels (pressure and/or vacuum). Each module can be upgraded at any time and have channels added or changed. You can control as many channels as you want with one computer.
Need more channels on one module (8, 16, 64…. or even more)? Our custom service would design a specific pressure controller that fits your needs.
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[testimonial_text] => We are using the device extensively at the moment and I have been quite impressed by its capabilities
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[testimonial_text] => After an easy installation, we are now using the OB1 and flow sensors routinely and are very satisfied by both the flow stability and the software user-friendly interface.
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[testimonial_university_country_v2] => Cell Growth Lab, Department of Experimental Plant Biology, Charles University, Czech Republic
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[testimonial_text] => We use Elveflow instrument in several projects and they are great to work with. The LabVIEW implementation was also very successful. I hope more people can get to know the OB1 system
[testimonial_author] => Seongjin Park, Senior Engineer
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[testimonial_university_country_v2] => Department of Physics, Syracuse University
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[testimonial_text] => We have used Elveflow's products for about 9 years now and are big fans, and have made lots of recommendations to friends in Wageningen and the Netherlands. They are so easy to use, reliable and the pricing is sharp. We are very happy customers!
[testimonial_author] => Prof. Dr. Joris Sprakel, Physical Chemistry and soft Matter, Wageningen university, Netherlands
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[text] => Check our MFS flow sensor
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Flow control systems 1 pages found
1 to 4 channels pressure vacuum microfluidic flow controller
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